Results 31 to 40 of about 317,098 (167)

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer

The Journal of Pathology, Volume 267, Issue 1, Page 40-55, September 2025.
Abstract The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have been obscure.
Joseph C Ward, Melissa Morgan, James Wood, Connor Woolley, Albert Antao Nobre de Menezes, Alina Finch, Kitty Sherwood, Qiwen Huang, Chloe S Henry, Juan Fernández‐Tajes, Ignacio Soriano, Steve Thorn, Isabelle Legge, James McCullagh, David Kerr, Rachel Kerr, Rahul K Hejmadi, Mark J Arends, The S:CORT Consortium, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean‐Baptiste Cazier, Enric Domingo, Andrew Blake, Che‐Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Philip Quirke, Manuel Salto‐Tellez, Les Samuel, Anna Schuh, David Sebag‐Montefiore, Matt Seymour, Ricky Sharma, Richard Sullivan, Ian Tomlinson, Nicholas West, Richard Wilson, Enric Domingo, Timothy Maughan, Chiara Bardella, Ian Tomlinson   +59 more
wiley   +1 more source

A movable stop mechanism for the SIRE telescope [PDF]

, 1982
A movable stop mechanism (MSM) designed to activate flaps that change the size and shape of a telescope aperture stop on command is described. Operating at the cryogenic temperatures of the optical system, it consists primarily of a rotary solenoid that ...
Poulsen, R. N., Tweedt, R. E.
core   +1 more source

Precision Measurements of the Semileptonic Charm Decays $D^0 \to \pi^- \ell^+ \nu$ and $D^0 \to K^- \ell^+ \nu$

, 2004
We investigate the decays $D^0\to\pi^-\ell^+\nu$ and $D^0\to K^-\ell^+ \nu$, where $\ell$ is $e$ or $\mu$, using approximately 7 ${\rm fb}^{-1}$ of data collected with the CLEO III detector. We find $R_0\equiv {\cal B}(D^0\to \pi^-e^+\nu)/{\cal B}(D^0\to
Ablikim M., Eidelman S., F. Liu, Gilman F. J., Okamoto M.   +4 more
core   +1 more source

The Supply Chain Adaptation of the Companies at Manaus Industrial Pole as a response to COVID-19 impacts

UFAM Business Review - UFAMBR
The COVID-19 pandemic, which in early 2020 led the world into a devastation, brought with it a series of challenges and significant changes that humanity needed to adapt to. Among the impacted areas, the global Supply Chain had a solid remark. The aim of this paper is to analyze the international logistic scenario from the Amazon region’s perspective ...
Antônio Giovanni Figliuolo Uchôa, Jonnathas Barroso Da Silva   +1 more
openaire   +1 more source

Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN‐TU‐001 trial

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Monoclonal anti‐amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose metabolism, and atrophy in trial participants with dominantly inherited Alzheimer's disease (DIAD). METHODS In the DIAN‐TU‐001
Austin McCullough, Charles D. Chen, Brian A. Gordon, Nelly Joseph‐Mathurin, Clifford R. Jack Jr, Robert Koeppe, Russ Hornbeck, Deborah Koudelis, Nicole S. McKay, Diana A. Hobbs, Shaney Flores, Sarah J. Keefe, Neelum T. Aggarwal, Ricardo F. Allegri, Sarah B. Berman, Thomas Bird, Sandra E. Black, William S. Brooks, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Nick C. Fox, Serge Gauthier, Lawrence S. Honig, Ging‐Yuek Hsiung, Mathias Jucker, Johannes Levin, Mario Masellis, Colin Masters, Patricio Chrem Mendez, John M. Ringman, B. Joy Snider, Stephen Salloway, Peter R. Schofield, Hiroyuki Shimada, Kazushi Suzuki, Christopher H. van Dyck, Gregory Klein, David B. Clifford, Carlos Cruchaga, Jason Hassenstab, Yan Li, Eric McDade, Susan Mills, John C. Morris, Richard J. Perrin, Charlene Supnet‐Bell, Guoqiao Wang, Chengjie Xiong, Randall J. Bateman, Tammie L. S. Benzinger, for the DIAN‐TU Study Team   +51 more
wiley   +1 more source

Tau, atrophy, and domain‐specific cognitive impairment in typical Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION A granular understanding of the mechanisms linking tau pathology to cognitive decline in Alzheimer's disease is crucial. We investigate mediating effects of medial temporal lobe (MTL) and neocortical neurodegeneration on tau‐induced domain‐specific cognitive impairment in amyloid‐beta (Aβ) positive cognitively normal and impaired ...
Anika Wuestefeld, Long Xie, Emily McGrew, Alexa Pichet‐Binette, Nicola Spotorno, Danielle van Westen, Niklas Mattsson‐Carlgren, Paul A. Yushkevich, Sandhitsu R. Das, David A. Wolk, Laura E. M. Wisse, and for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Evaluation of exercises designed to increase children's use of descriptive words. [PDF]

, 1951
Thesis (Ed.M.)--Boston ...
Georgas, Euphrosyne, MacPartlin, Anna I
core   +1 more source

Novel electrocardiographic criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy [PDF]

, 2015
Aims: In order to improve the electrocardiographic (ECG) diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC), we evaluated novel quantitative parameters of the QRS complex and the value of bipolar chest leads (CF leads) computed from the ...
Bastiaenen, Rachel, Batchvarov, Velislav N., Behr, Elijah R., Clark, Elaine, Macfarlane, Peter, Postema, Pieter G., Wilde, Arthur A.M.   +6 more
core   +1 more source

Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Sleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical thickness (CTh), but associations with objective sleep measures, particularly regarding sex and AD pathology, remain unclear.
Laura Stankeviciute, Núria Tort‐Colet, Ana Fernández‐Arcos, Gonzalo Sánchez‐Benavides, Carolina Minguillón, Karine Fauria, Sebastian Camillo Holst, Pilar Garcés, Thomas Mueggler, Henrik Zetterberg, Kaj Blennow, Álex Iranzo, Marc Suárez‐Calvet, Juan Domingo Gispert, José Luis Molinuevo, Oriol Grau‐Rivera, for the ALFA Study   +16 more
wiley   +1 more source

Multimodal spatial gradients to explain regional susceptibility to fibrillar tau in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION In Alzheimer's disease (AD), fibrillar tau gradually progresses from initial seed to larger brain area. However, those brain properties underlying the region‐dependent susceptibility to tau accumulation remain unclear. METHODS We constructed multimodal spatial gradients to characterize molecular properties and connectomic ...
Ying Luan, Lukai Zheng, Jannis Denecke, Amir Dehsarvi, Sebastian N. Roemer‐Cassiano, Anna Dewenter, Anna Steward, Sergey Shcherbinin, Diana Otero Svaldi, Vikas Kotari, Ixavier Alonzo Higgins, Michael J. Pontecorvo, Carolina Valentim, Julia A. Schnabel, Francesco Paolo Casale, Martin Dyrba, Stefan Teipel, Nicolai Franzmeier, Michael Ewers, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +19 more
wiley   +1 more source