Results 71 to 80 of about 128,313,875 (298)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Health behaviour in school-aged children : World Health Organization collaborative cross-national study (HBSC): findings from the 2010 HBSC survey in Scotland [PDF]

, 2011
The HBSC study in Scotland is funded by NHS Health ScotlandThe report, produced by CAHRU with funding support from NHS Health Scotland, provides a unique picture of the health of young people aged 11, 13 and 15 years in Scotland over the last two decades.
Currie, Dorothy Bruce, Levin, Kate Ann, van der Sluijs, Winfried, Kirby, Joanna Louise Michelle, Inchley, Joanna Catherine, Currie, Candace   +5 more
core   +2 more sources

Adolescent lives matter

Current Opinion in HIV and AIDS, 2018
Purpose of review Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be curtailed.
Pettifor, Audrey, Stoner, Marie, Pike, Carey, Bekker, Linda-Gail   +3 more
openaire   +3 more sources

Development of Adolescent Relationships [PDF]

, 2009
This dissertation on “Development of Adolescent Relationships” addresses relationships with parents, friends, and romantic partners in adolescence from a developmental perspective.
de Goede, I.H.A., Dep Educatie & Pedagogiek, Universiteit Utrecht, Adolescent development: Characteristics and determinants   +3 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Efficacy of an Individualized Computer-Assisted Social Competence Training Program for Children With Oppositional Defiant Disorders/Conduct Disorders

Frontiers in Psychiatry, 2019
Group-based child-centered cognitive behavioral therapy (CBT) for children with aggressive behavior has been found to significantly reduce child behavior problems.
Anja Goertz-Dorten, Anja Goertz-Dorten, Anja Goertz-Dorten, Manuela Groth, Kerstin Detering, Anne Hellmann, Laura Stadler, Barbara Petri, Manfred Doepfner, Manfred Doepfner, Manfred Doepfner   +10 more
doaj   +1 more source

Adolescent Anxiety: Development, Individual Vulnerability, and Social Relationships [PDF]

, 2015
The general aim of this dissertation was to extend current knowledge on the development of adolescent anxiety in the general population, by (1) examining developmental patterns of anxiety and individual differences in these patterns from childhood ...
Leerstoel Branje, Nelemans, S., Adolescent development: Characteristics and determinants   +2 more
core  

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

BLAME-LESS STUDY: a two-arm randomized controlled trial evaluating the effects of an online psychoeducation programme for adolescents who have experienced physical/sexual violence or sexual abuse. Rationale, study design, and methods

European Journal of Psychotraumatology
Background: Victims of physical/sexual violence or sexual abuse commonly experience defense responses that result in feelings of guilt and shame. Although trauma-focused interventions are effective in treating post-traumatic stress disorder symptoms, the
Rik Knipschild, Helen Klip, Katie Winkelhorst, Tessa Stutterheim, Agnes van Minnen   +4 more
doaj   +1 more source