Results 21 to 30 of about 175,765 (269)

Intertester reliability of shoulder complaints diagnoses in primary health care

Scandinavian Journal of Primary Health Care, 2016
Objective: Shoulder complaints are frequently encountered in general practice, but precise diagnosing is challenging. This study investigated agreement of shoulder complaints diagnoses between clinicians in a primary health care setting.
Benny Storheil, Elise Klouman, Stian Holmvik, Nina Emaus, Nils Fleten   +4 more
doaj   +1 more source

Complex lifestyle intervention among inactive older adults with elevated cardiovascular disease risk and obesity: a mixed-method, single-arm feasibility study for RESTART—a randomized controlled trial

Pilot and Feasibility Studies, 2021
Background Physical inactivity and obesity are global public health challenges. Older adults are important to target for prevention and management of disease and chronic conditions.
Trygve S. Deraas, Laila Hopstock, Andre Henriksen, Bente Morseth, Anne Sofie Sand, Inger Njølstad, Sigurd Pedersen, Edvard Sagelv, Jonas Johansson, Sameline Grimsgaard   +9 more
doaj   +1 more source

Advancing hyperspectral imaging techniques for root systems: a new pipeline for macro- and microscale image acquisition and classification

Plant Methods
Background Understanding the environmental impacts on root growth and root health is essential for effective agricultural and environmental management.
Corine Faehn, Grzegorz Konert, Markku Keinänen, Katja Karppinen, Kirsten Krause   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The Influence of Above-Ground Herbivory on the Response of Arctic Soil Methanotrophs to Increasing CH₄ Concentrations and Temperatures

Microorganisms, 2021
Rising temperatures in the Arctic affect soil microorganisms, herbivores, and peatland vegetation, thus directly and indirectly influencing microbial CH4 production.
Edda M. Rainer, Christophe V. W. Seppey, Caroline Hammer, Mette M. Svenning, Alexander T. Tveit   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Sedimentary DNA from lake depocenters maximizes detection of catchment vegetation

Communications Earth & Environment
Sedimentary DNA is becoming an invaluable tool for biodiversity assessments across spatial and temporal scales. Accurate interpretation, however, requires a clear understanding of its origin and taphonomy, from transport to preservation processes within ...
Tulug Gulce Ataman, Youri Lammers, Inger Greve Alsos, Dilli Prasad Rijal, Antony G. Brown   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Risk factors for perinatal mortality in Murmansk County, Russia: a registry-based study

Global Health Action, 2017
Background: Factors contributing to perinatal mortality (PM) in Northwest Russia remain unclear. This study investigated possible associations between selected maternal and fetal characteristics and PM based on data from the population-based Murmansk ...
Anna A. Usynina, Andrej M. Grjibovski, Alexandra Krettek, Jon Øyvind Odland, Alexander V. Kudryavtsev, Erik Eik Anda   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source