Results 71 to 80 of about 583,007 (361)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Attitudes toward the theory of evolution and its misconceptions in Tromsø, Northern Norway

Evolution: Education and Outreach
Background Evolution is the core of modern biology, but various misconceptions are persistent companions to the theory. The intuitively appealing but discredited suggestion that organisms innately tend to evolve in a predefined direction still lingers ...
Joel Vikberg Wernström, Vanessa Molin Paynter, Ossian Hagevi, Andreas Altenburger   +3 more
doaj   +1 more source

A circumpolar perspective on fluvial sediment flux to the Arctic ocean [PDF]

, 2002
Quantification of sediment fluxes from rivers is fundamental to understanding land‐ocean linkages in the Arctic. Numerous publications have focused on this subject over the past century, yet assessments of temporal trends are scarce and consensus on ...
Holmes, Robert M., McClelland, James W., Peterson, Bruce J.   +2 more
core   +2 more sources

Arctic methylmercury cycling

Science of The Total Environment, 2022
Anthropogenic mercury (Hg) undergoes long-range transport to the Arctic where some of it is transformed into methylmercury (MeHg), potentially leading to high exposure in some Arctic inhabitants and wildlife. The environmental exposure of Hg is determined not just by the amount of Hg entering the Arctic, but also by biogeochemical and ecological ...
Jonsson, Sofi, Mastromonaco, Michelle Nerentorp, Wang, Feiyue, Bravo, Andrea G., Cairns, Warren R.L., Chételat, John, Douglas, Thomas A., Lescord, Gretchen, Ukonmaanaho, Liisa, Heimbürger-Boavida, Lars-Eric   +10 more
openaire   +7 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

The Arctic [PDF]

Bulletin of the American Meteorological Society, 2021
Druckenmiller, Matthew, Moon, Twila, Thoman, Richard, Ballinger, Thomas, Berner, Logan, Bernhard, Germar, Bhatt, Uma, Bjerke, Jarle, Box, Jason, Brown, R., Cappelen, John, Christiansen, Hanne, Decharme, Bertrand, Derksen, C., Divine, Dmitry, Drozdov, D., Elias Chereque, A., Epstein, Howard, Farquharson, L., Farrell, Sinead, Fausto, Robert, Fettweis, Xavier, Fioletov, Vitali, Forbes, Bruce, Frost, Gerald, Gargulinski, Emily, Gerland, Sebastian, Goetz, Scott, Grabinski, Z., Grooss, Jens-Uwe, Haas, Christian, Hanna, Edward, Hanssen-Bauer, Inger, Hendricks, Stefan, Holmes, Robert, Ialongo, Iolanda, Isaksen, K., Jain, Piyush, Johnsen, Bjørn, Kaleschke, L., Kholodov, A., Kim, Seong-Joong, Korsgaard, Niels, Labe, Zachary, Lakkala, Kaisa, Lara, Mark, Loomis, Bryant, Luojus, K., Macander, Matthew, Malkova, G., Mankoff, Kenneth, Manney, Gloria, Mcclelland, James, Meier, Walter, Mote, Thomas, Mudryk, L., Müller, Rolf, Nyland, K., Overland, James, Park, T., Pavlova, Olga, Perovich, Don, Petty, Alek, Phoenix, Gareth, Raynolds, Martha, Reijmer, C., Richter-Menge, Jacqueline, Ricker, Robert, Romanovsky, Vladimir, Scott, Lindsay, Shapiro, Hazel, Shiklomanov, Alexander, Shiklomanov, Nikolai, Smeets, C., Smith, Sharon, Soja, Amber, Spencer, Robert, Starkweather, Sandy, Streletskiy, Dimitri, Suslova, Anya, Svendby, Tove, Tank, Suzanne, Tedesco, Marco, Tian-Kunze, X., Timmermans, Mary-Louise, Tømmervik, Hans, Tretiakov, Mikhail, Tschudi, Mark, Vakhutinsky, Sofia, van As, Dirk, van de Wal, R., Veraverbeke, Sander, Walker, Donald, Walsh, John, Wang, Muyin, Webster, Melinda, Winton, Øyvind, Wood, K., York, Alison, Ziel, Robert   +99 more
openaire   +4 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Safeguarding Important Areas in the U.S. Arctic Ocean [PDF]

, 2015
The U.S. Arctic Ocean supports unique species found nowhere else in the country and is home to indigenous Inupiat people who have thrived on its bounty for thousands of years.

core  

Spatial Differentiation of the Economic Structure of the Russian Regions of the Arctic Zone [PDF]

, 2015
The Regions located in the Arctic zone of the Russian Federation implement an important function in the development of an export potential of the country. The richest nature-resource potential of the land and the sea should be considered as the favorable
Baklanov, P. Ya., Moshkov, A. V.
core   +1 more source