Results 31 to 40 of about 1,066 (237)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

The Siege and Capture of the Polatsk Fortress by the His Majesty Stephen, the King of Poland – the Use of Cartography in Tactical Planning

, 2017
The siege of Polatsk is not the first example of the application of cartographic plans in siege operations conducted by the Crown or Lithuanian armies. We should mention the capture of Uła in 1568 or the battle at Latarnia in 1577.
Łopatecki, Karol
core   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Fortress of Ochakov (1768-1792)

, 2023
Özi Nehri’nin Karadeniz ile buluştuğu yerde kurulmuş olan Özi Kalesi, jeopolitik konumu nedeniyle Karadeniz’e hakim olmak isteyen birçok devletin siyasi, askeri ve ticari mücadelesinin yaşandığı bir yer olmuştur.
Kahya, Ozan
core  

About an Unknown Letter “from the Newly Conquered City of Areshek” [PDF]

, 2023
The article was submitted on 15.03.2023.В фондах РНБ хранится рукописная книга «Сборник военных писем».Она представляет собой рукопись, в которой переписаны тексты сообщений о боевых действиях частей русской армии в 1702–1710 гг.
Alekseev, А., Алексеев, А. И.
core   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

The Cost of a Nutritious Diet in Cafeterias: Evidence From US Military Dining Facilities

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Providing nutritious meals in institutional settings with financial constraints, such as military dining facilities, is challenging. The US Department of War (DoW) and US Department of Agriculture (USDA) collaborated to modernize the Basic Daily Food Allowance (BDFA) using an optimization model that incorporates service members' consumption ...
Linlin Fan, Yiwen Zhao, Andrea Carlson, Parke Wilde, Joanna Reagan, Julianna Jayne, Starr Seip, Denise Laursen, Matthew P. Rabbitt   +8 more
wiley   +1 more source

THE ORIGINS OF THE SEVEN YEARS' WAR IN NORTH AMERICA

Вестник Брянского государственного университета
The colonial conflicts in North America became the harbingers of the Seven Years' War, one of the most significant military conflicts of the XVIII century.
Kolesnikov P.A.
doaj   +1 more source

Wine Tourism as a Catalyst for Sustainable Performance: The Mediating Role of Corporate Legitimacy and Green Innovation

Agribusiness, EarlyView.
ABSTRACT This study aims to explore the influence of Wine Tourism (WT) on the Sustainable Performance (SP) of wineries in Spain. It particularly investigates how Corporate Social Legitimacy (CSL) and Green Innovation (GI) may act as intermediary factors in this relationship.
Javier Martínez‐Falcó, Eduardo Sánchez‐García, Bartolomé Marco‐Lajara, Luis A. Millán‐Tudela   +3 more
wiley   +1 more source

Sometimes at the Cross-roads: Preliminary Results from New Fieldwork on the Southeast Ararat Plain of Armenia

, 2021
The Ararat Plain, part of the upper Araxes River valley system in the South Caucasus mountains, represents the largest expanse of arable land in Armenia today.
Cobb, PJ
core