Results 51 to 60 of about 409,591 (393)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The views of the child: Article 12 and the development of children's rights in Scotland [PDF]

open access: yes, 2000
Article 12 of the UN Convention on the Rights of the Child calls for state parties to 'assure to the child who is capable of forming his or her own views the right to express those views freely in all matters affecting the child, the views of the child ...
Kendrick, Andrew
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

The Right of Child Victims of Armed Conflict to Reintegration and Recovery

open access: yesPotchefstroom Electronic Law Journal, 2012
Article 39 of the Convention on the Rights of the Child provides for the right to recovery and reintegration of child victims of armed conflict. In this publication an explanation is tendered of when children are considered to be victims of armed ...
JA Robinson
doaj  

CONSTRUCTING CRITICAL CITIZENSHIP WITH YOUNG PEOPLE: ALTERNATIVE PEDAGOGIES

open access: yesInternational Journal of Child, Youth & Family Studies, 2011
The authors present theoretical and empirical arguments for adopting the United Nations Convention on the Rights of the Child (or CRC) to renew the teaching of citizenship to young students from a social justice standpoint (Giroux, 2003; Giroux & Searls-
Shannon Moore
doaj   +1 more source

Child Rights during the COVID-19 Pandemic: Learning from Child Health-and-Rights Professionals across the World

open access: yesChildren, 2023
The COVID-19 pandemic underscores the importance of a child rights-based approach to policymaking and crisis management. Anchored in the United Nations Convention on the Rights of the Child, the 3P framework—provision, protection, and participation—forms
Eva Jörgensen   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Ósýnileiki barna sem leita alþjóðlegrar verndar á Íslandi í fylgd foreldra

open access: yesNordicum-Mediterraneum, 2019
Invisibility of children of asylum-seeking families in Iceland According to the Convention on the Rights of the Child, asylum-seeking children should be given the same rights as other children in Iceland.
Helga Gudmundsdóttir   +2 more
doaj  

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