Results 181 to 190 of about 276,427 (262)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Causal effect of school-entry age on long-run family formation: Quasi-experimental evidence from 14 million individuals in Vietnam. [PDF]

PNAS Nexus
Busireddy I, Liao J, Vu DH, Tran TNM, De Neve JW.   +4 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Late Cenozoic exhumation in the eastern Junggar Basin: Evidence from zircon (U-Th)/He ages of combustion metamorphic rocks. [PDF]

PLoS One
Chen B, Liu P, Dong Y, Feng C, Zhao Z, Yang C, Dong Y.   +6 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Bidirectional Links Between Maternal and Adolescent Depression: Separating Between and Within Dyad Differences. [PDF]

J Clin Child Adolesc Psychol
Seidman SB, Magee KE, Connell AM, Ha T, Westling E, Brown-Iannuzzi J, Stormshak E, Shaw DS.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A ∼0.5 Myr perturbation of carbon and mercury cycles during the Middle Triassic biotic radiation. [PDF]

Sci Adv
Cao Y, Chu D, Yin R, Song H, Dal Corso J, Ovtcharova M, Gianolla P, Grasby SE, Benton MJ, Dai X, Alverà G, Roghi G, Caggiati M, Schneider-Mor A, Korngreen D, Tong J.   +15 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Shifting epidemiology and disease severity: Rethinking India's hepatitis A strategy in the context of acute liver failure. [PDF]

J Family Med Prim Care
Bhadoria AS, Anirvan P, Roy A, Bose R, Kumar R.   +4 more
europepmc   +1 more source