Results 151 to 160 of about 186,902,381 (301)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Caribbean Report 19-02-2001

, 2001
1. Headlines (00:00-00:28)2. Politics of race worry Guyanese but it is the independence question that is dividing one new party in Montserrat. Leader of the Political Party Rise, Organise and Rebuild Ravi Dev, Leader of Guyana Action Party Hardy Paul ...
Joseph, Emma (correspondent), Aristide, Bertrand (correspondent), Osborne, John (interviewee), Dev, Ravi (interviewee), Wheare, Karen (anchor), Banks, Ali (interviewee), Arthur, Owen (interviewee), Hardy, Paul (interviewee), Ramphal, Shridath (interviewee), Brown, Shedman (interviewee), The British Broadcasting Corporation, Smith, Colin (correspondent), Compton, John (interviewee), Niles, Bertram (anchor)   +13 more
core  

"They were saying that it's the end of the world": Experiences of COVID-19 and beliefs about the COVID-19 vaccine among refugees in Rhode Island, US. [PDF]

Hum Vaccin Immunother
Connolly S, Liebermann E, Greaney ML, Cohen SA, Lindsey H, Prue O, Keller JC.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Biennial report of the Comptroller of the State of Connecticut to the General Assembly, ...

Description based on: 1888.Report year end varies: it ends June 30 from 188 -1890; it ends Sept. 30 from 1892-1894.Mode of access: Internet.Continued by: Connecticut. Office of the State Comptroller.
Connecticut. Office of the State Comptroller.
core  

Competing interests, appeals and trial registration in the Bulletin.

, 2005
64564
The Bulletin of the World Health Organization
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It's the end of the world and we feel fine. [PDF]

J Med Libr Assoc, 2015
Williams JD, Rambo NH.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Caribbean Report 16-05-2000

, 2000
1. Headlines: (00:00-00:26)2. Britain’s Department of International Development is blaming the absence of paediatric care on Montserrat for an advisory barring children under 12 from visiting the island due to the volcanic risk.
Young, Simon (interviewee), Reinert, Rick (interviewee), Goffe, Leslie (correspondent), Caroit, Jean-Michel (correspondent), Gordon, Orin (anchor), Andrew, Kimberley (correspondent), The British Broadcasting Corporation   +6 more
core  

Reduced type 2 diabetes incidence reflecting end of post‑World War II calorie restrictions in Germany. Reply to Nilsson PM, Vaag A [letter]. [PDF]

Diabetologia
Lehner CT, Schauberger G, Klug SJ.
europepmc   +1 more source