Results 231 to 240 of about 186,902,381 (301)

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Hearing Smarter: A Scoping Review of Artificial Intelligence Implementation in Hearing Devices. [PDF]

J Clin Med
Hanegan C, Andos A, Ranganath R, Ezeldin A, Price H, Ford J, Mangan A, Richter G.   +7 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

No End of Worlds

, 2019
openaire   +1 more source

First-line treatment patterns and real-world survival outcomes in PD-L1-negative locally recurrent inoperable or metastatic triple-negative breast cancer in the United States. [PDF]

Breast Cancer Res Treat
Traina TA, Serra E, Bedard J, Levesque-Leroux M, Gagnon-Sanschagrin P, Guérin A, Guenther S, Joseph G, Guan V, Salcedo J.   +9 more
europepmc   +1 more source

Cardiac Resynchronization as an Enabler of ARNI Efficacy: Insights From a Real-World Cohort. [PDF]

J Arrhythm
Santoro A, Spaccaterra L, Collantoni M, Baiocchi C, Natali BM, Lunghetti S, Pagliaro A, Manetti N, Morrone F, Fineschi M, Palazzuoli A.   +10 more
europepmc   +1 more source

A Robotic Picking Framework for Autonomous Singulation of Sweetpotato Slips into Chainpots. [PDF]

Sensors (Basel)
Raj P, He W, Brown A, Chen Y, Zahid A, Xiang L.   +5 more
europepmc   +1 more source

The end of the world or the end of Capitalism?

, 2016
openaire   +1 more source