Results 41 to 50 of about 639,249 (307)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
A Citizens Compact: Reaching out to the Citizens of Europe. CEPS EPIN Working Papers No. 14, 1 September 2005 [PDF]
, 2005 [Executive Summary]. How can the deadlock after the ‘no’ to the European Constitutional Treaty in France and the Netherlands be overcome? What should be the aim of the ‘period of reflection’ that has been agreed by the European Council?
Crum, Ben +12 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Nanomaterials, 2018 Synthesizing phosphors with high performance is still a necessary work for phosphor-converted white light-emitting diodes (W-LEDs). In this paper, three series of CaAlSiN3:Eu2+ (denoted as CASN:Eu2+) phosphors using Eu2O3, EuN and EuB6 as raw materials ...
Wen-Quan Liu +8 more
doaj +1 more source
The europeanization of the common road safety policy: an econometric analysis [PDF]
, 2013 The 2001 White Paper and its development in the 3rd European Road Safety Action Program, represent a turning point in the history of the European Road Safety Policy.
Castillo Manzano, José I. +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
EU-Centric Governance in Sport? The Slovenian Experience with the White Paper Process
Journal of Contemporary European Research, 2007 A synthesis of existing academic, expert and everyday practical political literature demonstrates that we can trace many different approaches to the phenomena of governance. Based on the political sciences, particularly policy literature, the governance concept is most frequently connected with an analysis of the relations between actors or ...
openaire +3 more sources
Transport and sustainability, with special regard to the EU Transport White Paper of 2011 [PDF]
, 2011 The EU transport policy in 2001 took the environmental imperatives seriously and focused on curbing road transport. This brought strong reactions, and the 2006 reappraisal betrayed an intention of allowing that objective to atrophy.
Fleischer, Tamás
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