Results 71 to 80 of about 178,734,979 (261)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Managing Consumer Expectations of Services

Marketing Management Journal, 1993
Future patronage decisions of service firms are closely linked to the quality of service and the level of satisfaction experienced during past and current service encounters.
DAVID L. KURTZ, KENNETH E. CLOW
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Forensically-Sound Analysis of Security Risks of using Local Password Managers [PDF]

, 2016
Password managers have been developed to address the human challenges associated with password security, i.e., to solve usability issues in a secure way.
Gray, Joshua, Joshua Gray, Yijun Yu, Franqueira, Virginia N. L., Virginia N. L. Franqueira, Franqueira, Virginia N.L., Yu, Yijun   +6 more
core   +1 more source

Coproduction investments: Street-level management perspective on coproduction

Cogent Business & Management, 2019
Although public managers are considered to substantially influence coproduction, current research concentrates on service users and communities’ perspectives, whereas the contribution of the public workers is understudied.
Drorit Gassner, Anat Gofen
doaj   +1 more source

Acceptance factors of telemedicine in times of COVID-19: Case Argentina [PDF]

Pharmacia
We performed an analytical, cross-sectional study of 285 consumers to assess the influence of social influence, resistance to use, facilitators to use, perceived ease of use and perceived usefulness of telemedicine on the intention to use telemedicine of
Jorge Anibal Schlottke, Aldo Alvarez-Risco, Ezequiel Leandro Bertiche, Rocío Belén López, Carla Vanesa Torletti, Facundo Yamil del Hoyo, Shyla Del-Aguila-Arcentales, Christian R. Mejia, Mercedes Rojas-Osorio, Neal M. Davies, Jaime A. Yáñez   +10 more
doaj   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Wizerunek osobowościowy współczesnego menedżera w przedsiębiorstwie

Przedsiębiorczość - Edukacja, 2007
To succeed in a global and integrated economy, various organizations – especially in business – need the efficient management and be able to cooperate with a lot of institutions; alsothey need to fulfill expectation of their partners and customers as ...
Paweł Żukowski
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source