Results 41 to 50 of about 214 (191)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Classification and ecological relevance of soundscapes in urban informal settlements
People and Nature, 2023 Sound exerts wide‐ranging influence on humans. The quality of that influence depends on the sound source and context in which it is perceived, but nature sounds are generally preferred by people and associated with health and well‐being benefits. In many
Genie M. Fleming +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
PLoS ONE, 2020 MethodsMuscle sections were stained for cell boundary (laminin) and myofiber type (myosin heavy chain isoforms). Myosoft, running in the open access software platform FIJI (ImageJ), was used to analyze myofiber size and type in transverse sections of ...
Lucas Encarnacion-Rivera +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Caring for the Environment and the Mitigation of Natural Extreme Events in Gau Island, Fiji Islands [PDF]
Island Studies Journal, 2006 Since 2001, the villagers in Vanuaso Tikina, Gau Island, Fiji, have collaborated with the University of the South Pacific to manage their environmental resources to prepare them for difficult and challenging times ahead.
Joeli Veitayaki
doaj
Geophysical Research Letters, 2016 Regional waveforms of deep‐focus Tonga‐Fiji earthquakes indicate anomalous traveltime differences (ScS2‐ScS) and amplitude ratios (ScS2/ScS) of the phases ScS and ScS2.
Carlos A. M. Chaves, Jeroen Ritsema
doaj +1 more source
Microstructural Evaluation of an Austempered Cast Iron Alloy
Materials Research, 2022 ADI are the result of graphite nodules and ausferrite microstructure (acicular ferrite + retained austenite). Over the past few years, ADI has become an important material for engineering due to its excellent mechanical properties (outstanding ductility,
Letyssia Niara De Godoi Pereira +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source