Results 41 to 50 of about 69,612 (260)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Where are the women candidates during elections? A Fiji media case study

Pacific Journalism Review, 2013
This article examines the visibility of female election candidates, and females in general, in The Fiji Times and Fiji Sun during the 2006 general election.
Shazia Usman
doaj   +1 more source

Real-time qPCR improves meningitis pathogen detection in invasive bacterial-vaccine preventable disease surveillance in Fiji [PDF]

Scientific Reports, 2016
AbstractAs part of the World Health Organization Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) surveillance in Suva, Fiji, cerebrospinal fluid (CSF) samples from suspected meningitis patients of all ages were examined by traditional methods (culture, Gram stain, and latex agglutination for bacterial antigen) and qPCR for Streptococcus ...
Dunne, EM, Mantanitobua, S, Singh, SP, Reyburn, R, Tuivaga, E, Rafai, E, Tikoduadua, L, Porter, B, Satzke, C, Strachan, JE, Fox, KK, Jenkins, KM, Jenney, A, Baro, S, Kim Mulholland, E, Kama, M, Russell, FM   +16 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Times of sand: Sedimentary history and archaeology at the Sigatoka Dunes, Fiji

Geoarchaeology, 2006
The orthodox archaeological sequence at the Sigatoka Dunes site (VL 16/1) in Fiji proposes three phases of occupation spanning Fijian prehistory, each associated with a period of dune stability. It has been taken as the standard model of Fijian prehistory for more than 30 years.
Anderson, Atholl, Roberts, Richard, Dickinson, William, Clark, Geoffrey, Burley, David, de Biran, Antonie, Hope, Geoffrey, Nunn, Patrick   +7 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Classification and ecological relevance of soundscapes in urban informal settlements

People and Nature, 2023
Sound exerts wide‐ranging influence on humans. The quality of that influence depends on the sound source and context in which it is perceived, but nature sounds are generally preferred by people and associated with health and well‐being benefits. In many
Genie M. Fleming, Moataz M. ElQadi, Ruzka R. Taruc, Autiko Tela, Grant A. Duffy, Emma E. Ramsay, Peter A. Faber, Steven L. Chown   +7 more
doaj   +1 more source

A Time Bomb Lies Buried: Fiji’s Road to Independence, 1960-1970 [PDF]

, 2008
A Time Bomb Lies Buried discusses the debates which took place in Suva and London as well as the politics and processes which led Fiji to independence in 1970 after 96 years of colonial rule. It provides an essential background to understanding the crises and convulsions which have haunted Fiji ever since in its search for a constitutional settlement ...
openaire   +4 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source