Results 31 to 40 of about 126,944,329 (258)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Green’s function of the cable equation.

, 2019
A: Green’s function for various distances x. B: Green’s function for x = 1mm, showing the slow (dotted) and fast (dash-dotted) approximation.
Helmut Schmidt (248902), Thomas R. Knösche (7513382)   +1 more
core   +1 more source

Unified Green’s Function Retrieval by Cross Correlation [PDF]

, 2006
It has been shown by many authors that the cross correlation of two recordings of a diffuse wave field at different receivers yields the Green’s function between these receivers.
Snieder, R. (author), Slob, E.C. (author), Snieder, R., Wapenaar, C.P.A. (author), Wapenaar, C.P.A., Slob, E.C.   +5 more
core   +2 more sources

The Neural Network Fitting Method for Green’s Function of Finite Water Depth

Journal of Marine Science and Engineering
In marine hydrodynamics, the core of the boundary element method (BEM) lies in the numerical calculation of the free-surface Green’s function. With the rise of artificial intelligence, using neural networks to fit Green’s function has become a new trend,
Wenhui Xiong, Zhinan Mi, Yu Liu, Lunwei Zhang   +3 more
doaj   +1 more source

MATRIX GREEN’S FUNCTION OF DOUBLE-DIFFUSIVITY PROBLEM AND ITS APPLICATIONS TO PROBLEMS WITH INNER POINT SOURCE

TASK Quarterly, 2019
The matrix Green’s function of the initial-boundary value problem of admixture double-diffusivity is defined. The initial-boundary value problem with a point source is formulated for the matrix elements for determination of the matrix Green’s function ...
YEVHEN CHAPLYA, OLHA CHERNUKHA, YURII BILUSHCHAK   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Nonreciprocal Green’s function retrieval by cross correlation

, 2006
The cross correlation of two recordings of a diffuse acoustic wave field at different receivers yields the Green’s function between these receivers. In nearly all cases considered so far the wave equation obeys time-reversal invariance and the Green’s ...
Wapenaar, C.P.A. (author), Wapenaar, C.P.A.   +1 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source