Results 221 to 230 of about 461,298 (339)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Antagonistic SMAD2/3 control of TIMP-1, VEGF-A, and hypoxia signaling in myofibroblasts shapes histotype-specific angiogenesis in lung cancer. [PDF]

Cell Death Dis
Díaz-Valdivia N, Duch P, Ikemori R, Parker AL, Arshakyan M, Llorente A, Bernardo A, Rodríguez-Rojas J, Carrasco JL, Park D, Sahai E, Fillat C, Juan M, Nadal E, Reguart N, Radisky DC, Casanovas O, Alcaraz J.   +17 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Camera-Trap Evidence of <i>Myricaria</i> sp. Consumption and Head-Rubbing by a Wild Snow Leopard (<i>Panthera uncia</i>) in an Alpine Ecosystem. [PDF]

Ecol Evol
Kinoshita K, Yoshimura H, Zhumabai Uulu K, Sharma K, Sergek Uulu A, Djaparov E, Tolok Uulu K, Kikuchi DM.   +7 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Electrocardiographic Manifestation of Modulated Parasystole With Variable Escape Timing. [PDF]

JACC Case Rep
Doss R, Nathan K, Jaiswal J, Kutalek SP, Gupta A.   +4 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Antimutagenic effects of a tea made from Actinidia arguta, sarunashi in Japanese, and its inhibitory effects on the formation of aberrant crypt foci induced by 1,2-dimethylhydrazine in mice. [PDF]

Genes Environ
Saiki Y, Miyake N, Arimoto-Kobayashi S.
europepmc   +1 more source

The Idea of the Devil and the Problem of the Indian: the case of Mexico in the sixteenth century

, 1991
Cervantes, Fernando
core