Results 191 to 200 of about 199,138 (264)

Strengthening Clinical Epidemiology in Somalia: Challenges, Opportunities, and Future Directions. [PDF]

Clin Epidemiol
Abdi IA.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Research trends in total knee arthroplasty in India: a five-year bibliometric analysis. [PDF]

Arch Orthop Trauma Surg
Shetty S, Vijayan S, Mohandas Rao KG, Rao SK, Nayak Y, George BM.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A study on the current status of collaboration between China's commercial health insurance and medical institutions and improvement strategies. [PDF]

BMC Health Serv Res
Ma P, Si W, Zhou Y, Huang L.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Developmental co-calibration and therapeutic recalibration: a neurobiopsychosocial model of regulatory path dependence in psychosomatic care. [PDF]

Front Psychiatry
Niederlohmann E.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Feasibility of a Stool State Check App Using AI During Bowel Preparation Before Colonoscopy: Multicenter Prospective Study (SCAN Study). [PDF]

JMIR Mhealth Uhealth
Inaba A, Shinmura K, Osera S, Yamada T, Kon H, Kanazawa M, Sugimura N, Sano Y, Hosaka H, Uraoka T, Sato D, Yoda Y, Takamaru H, Saito Y, Gocho T, Katagiri A, Yamaguchi K, Matsuda T, Imai A, Fujimoto H, Matsuzaki H, Takeshita N, Wakabayashi M, Ikematsu H, Yano T.   +24 more
europepmc   +1 more source