Results 111 to 120 of about 2,938,705 (290)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease

Alzheimer’s Research & Therapy
Background Although interactions between amyloid-beta and tau proteins have been implicated in Alzheimer's disease (AD), the precise mechanisms by which these interactions contribute to disease progression are not yet fully understood.
Akihiro Kitani, Yusuke Matsui, for the Alzheimer’s Disease Neuroimaging Initiative   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Improving Early Literacy in PreK-3: Lessons Learned [PDF]

, 2016
In 2011, The McKnight Foundation partnered with a set of districts and schools in the Twin Cities area, all serving high-needs students, on a PreK–3 literacy initiative.
Katrina Woodworth, Lauren Cassidy, Shari Golan   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

An analysis of the cultivation, consumption and composition of home-grown cannabis following decriminalisation in the Australian Capital Territory

Scientific Reports
The Australian Capital Territory (ACT), a region that includes Australia’s capital, Canberra, decriminalised small-scale cannabis cultivation and possession in January 2020.
Cilla Zhou, Isobel Lavender, Rebecca Gordon, Danielle McCartney, Richard C. Kevin, Miguel A. Bedoya-Pérez, Iain S. McGregor   +6 more
doaj   +1 more source

The U.S. Global Health Initiative: Key Issues [PDF]

, 2010
Explores issues of GHI governance, funding allocation, impact measurement, ownership by recipient countries, international partnerships, implementing focus on women and girls, health systems strengthening, and coordination with foreign aid reform ...

core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Data-Driven Image-Based Protocol for Brain PET Image Harmonization

Sensors
Quantitative FDG-PET brain imaging across multiple centers is challenged by inter-scanner variability, impacting the comparability of neuroimaging data.
Eva Štokelj, Urban Simončič, for the Alzheimer’s Disease Neuroimaging Initiative   +2 more
doaj   +1 more source

Massachusetts Offshore Wind Future Cost Study [PDF]

, 2016
The Special Initiative on Offshore Wind is an independent project at the University of Delaware's College of Earth, Ocean and Environment that supports the advancement of offshore wind as part of a comprehensive solution to the most pressing energy ...
Deniz Ozkan, Stephanie McClellan, Willett Kempton   +2 more
core