Results 121 to 130 of about 2,938,705 (290)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Neural Representations of Neuropsychiatric Symptoms in Alzheimer's Disease Continuum Using Pathology‐Based Functional Connectivity Analysis

Brain and Behavior
Objectives: Neuropsychiatric symptoms (NPS) in the Alzheimer's disease continuum affect the quality of life for patients and caregivers. Therefore, elucidating the mechanisms of NPS is needed to better understand NPS and enhance patient care.
Taein Lee, Yong Jeong, for the Alzheimer's Disease Neuroimaging Initiative#   +2 more
doaj   +1 more source

Strengthening responsive and reciprocal relationships in a whānau tangata centre: An action research project [PDF]

, 2009
This project came about after discussions with the general manager of the Wellington Region Free Kindergarten Association and Jeanette Clarkin-Phillips (University of Waikato) about setting up a research partnership to support the teachers at Taitoko ...
Carr, Margaret, Clarkin-Phillips, Jeanette   +1 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Partners in Excellence : Evaluation Report [PDF]

, 2004
This is the final report on the 'Partners in Excellence' initiative, which was funded by the Scottish government, and aimed at increasing motivation for language learning in the upper secondary school, using a variety of stimulants including the use of ...
Doughty, Hannah, Johnstone, Richard, Malcolm, Irene, Scottish Executive Education Department (Funder)   +3 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Strengthening Organizations to Mobilize Californians: Lessons Learned from a Major Initiative to Build the Capacity of Civic Engagement Nonprofits [PDF]

, 2011
From 2008 to 2010, twenty-seven community organizing nonprofits in California took part in an unusual and ambitious statewide initiative, Strengthening Organizations to Mobilize Californians (the "Initiative").
Paul Connolly, Susan Misra
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The spectrum initiative : affirmative action in the library profession [PDF]

, 2008
In 1998, the American Library Association realized its long-awaited dream, a major diversity initiative, the Spectrum Scholarship, which would address the rapidly changing ethnic and cultural environment of the nation.
Kenney, Barbara
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source