Results 131 to 140 of about 127,858,707 (311)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Fast implementation of density-weighted average derivative estimation

, 1995
Given random variables X isin R/sup d/ and Y such that E[Y|X=x]=m(x), the average derivative delta /sub 0/ is defined as delta /sub 0/=E[ nabla m(X)], i.e., as the expected value of the gradient of the regression function.
Proceedings of 26th Symposium on the Interface of Computing Science and Statistics (INTERFACE '94), Turlach, B.A.   +1 more
core  

Dynamics of organic matter in algal blooms on the Greenland ice sheet

Scientific Reports
Surface melting supports the development of pigmented algal blooms on the Greenland Ice Sheet, decreasing albedo and further accelerating melting. The interplay between carbon-fixing algae and carbon-respiring heterotrophic microorganisms ultimately ...
Pamela E. Rossel, Runa Antony, Rey Mourot, Thorsten Dittmar, Alexandre M. Anesio, Martyn Tranter, Liane G. Benning   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage assisted behavioral innovation and testing system

eLife
Mice are among the most prevalent animal models used in neuroscience, benefiting from the extensive physiological, imaging, and genetic tools available to study their brain.
Bowen Yu, Penghai Li, Haoze Xu, Yueming Wang, Kedi Xu, Yaoyao Hao   +5 more
doaj   +1 more source

Interfacing [PDF]

Current Biology, 1997
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Fundamentals of interface phenomena in advanced bulk nanoscale materials [PDF]

, 2005
The review is devoted to a study of interface phenomena influencing advanced properties of nanoscale materials processed by means of severe plastic deformation, high-energy ball milling and their combinations.
Sort, J., Suriñach, S., S. Suriæach, S. G. Protasova, Zhilyaev, A. P., M. J. Starink, Ovidko, I.A., Grabovetskaya, G.P., Langdon, T. G., Baró, M. D., Straumal, B.B., J. Gubicza, Langdon, T.G., Révész, Á., Ivanov, M. B., Protasova, S. G., Ungár, T., M. D. Baró, J. Noguøs, G. P. Grabovetskaya, J. Lendvai, Lipnitskii, A.G., Lipnitskii, A. G., Kolobov, Y. R., Yu. R. Kolobov, N. V. Skiba, Kolobov, Yu.R., Raab, G. I., B. B. Straumal, Gubicza, J., Nazarov, A. A., Mazilkin, A. A., Ivanov, M.B., Skiba, N.V., Protasova, S.G., T. G. Langdon, J. Sort, G. I. Raab, A. A. Nazarov, Raab, G.I., Starink, M.J., Nazarov, A.A., Zhilyaev, A.P., Révész, Ádám, Skiba, N. V., I. A. Ovidko, Baró, M.D., Baretzky, B., Ovidko, I. A., M. B. Ivanov, A. A. Mazilkin, Lendvai, János, Starink, M. J., T. Ungær, Grabovetskaya, G. P., Ungár, Tamás, Kolobov, Yu. R., Nogués, J., Mazilkin, A.A., B. Baretzky, Gubicza, Jenő, Lendvai, J., A. G. Lipnitskii, Straumal, B. B.   +63 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Brain-Computer Interface

, 2007
through measuring cerebral response to an interesting visual ...
Brain-computer Interface
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