Results 41 to 50 of about 527,814 (269)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Online Game Addiction and Gen Z: A Comparative Study on Turkish and Romanian High School Students
Selçuk İletişim, 2021 As being among “the digital natives” of the technology era, Generation Z and their online behaviors are important subjects to study in depth. Surrounded by technology, Generation Z is easily getting and using all technology products, and they do not feel
Huri Deniz Karcı, Bahar Urhan
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
How Parents of Children with Cancer Seek Information Through Online Communities: A Netnography Study
Journal of Pediatric Research, 2019 Aim:This study aims to examine how parents of children with cancer seek information through online communities, using netnography methods from qualitative study types.Materials and Methods:The study was carried out through two online communities where ...
Canan Sümeyra Gün, Selmin Şenol
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Czecho-Slovak Community in the Field of Contemporary Fan Fiction. The Case of the Harry Potter Fandom [PDF]
Slovenska Literatura, 2019 The goal of the paper is to map the Czecho-Slovak community in the field of contemporary fan fiction inspired by the Harry Potter series written by J. K.
Tereza Šmídová, Marcin Filipowicz
doaj
ANALYSIS OF METHODICAL DEFECTS IN PHD AND DOCTORAL THESIS ON ECONOMICS
Образование и наука, 2016 The aim of the article is to consider the most typical defectswhich can be found in PhD and doctoral dissertations on economic sciences. The research is based on a work experience of the author as the member of dissertation council, the reviewer and the ...
R. D. Gutgarts
doaj +1 more source