Results 61 to 70 of about 100,459 (218)

BİLGİTEKNOLOJİLERİNDEKİGELİŞMELER ÇERÇEVESİNDE BİLGİYE ERİŞİMİN YENİBOYUTLARI

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2005
20. yüzyılın sonlarından itibaren yaygınlaşmaya başlayan bilgi teknolojileri kullanım alanlarınıhızla genişletmektedir. Bilgi teknolojilerindeki hızlıgelişim, insanların bilgisayarlar yardımıyla istedikleri bilgiye zahmetsizce ulaşmasınısağlamaktadır. Bu
Tülay Bektaş Şeker
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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Contemporary social interaction: How communication technologies alter Goffman's dramaturgical model?

Ho Chi Minh City Open University Journal of Science - Social Sciences, 2015
The dramaturgical model in sociology was developed by Erving Goffman in his famous work “The Presentation of Self in Everyday life” published in 1959. This theoretical model views social life as a stage on which an individual plays a role of performer ...
Nguyen Trung Kien
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Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Comparative Study on Medical and Nursing Students Viewpoints about Telemedicine Procedures Development

Preventive Care in Nursing and Midwifery Journal, 2014
Background and Objectives: The aim of this study was to compare the viewpoints of medical and nursing students on development of telemedicine procedures at Mazandaran University of Medical Sciences. Materials and Methods: This was a cross-sectional study.
Ahad Alizade, Akbar Mohammadi, Hadi Hosseini, Mohammad Khadmloo   +3 more
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Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

ANALYSIS OF THE STARTING LEVEL OF COMPUTER DEPENDENCE OF STUDENTS

Вестник Северо-Кавказского федерального университета, 2022
Modernization of the modern education system, the availability of computer technology is one of the most striking events of our time. Almost every educational institution or organization is equipped with a computer and computer networks.
Y. Kulikova, T. Penkova
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