Results 61 to 70 of about 6,473 (264)

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Soils and Cultural Layer of Voznesenskoye I Settlement

Археология евразийских степей
The article examines the processes of cultural layer formation and their relationship with lithological, soil-forming, and other exogenous phenomena, which together constitute a unified natural-anthropogenic complex of processes.
Aleksandr L. Aleksandrovsky
doaj   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Diet, Cooking and Cosmology - Interpreting the Evidence from Bronze Age Plant Macro fossils

Current Swedish Archaeology, 1999
The aim of the article is to discuss how the composition of Bronze Age macrofossil samples reflects different aspects of daily life like diet and cooking.
Peter Skoglund
doaj   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Late Bronze Age settlements in the Visun and the Lower Ingulets rivers basin

Tyragetia, 2020
This work continues the series of publications on Late Bronze Age sites published in the Tyragetia journal in 2018 and 2019. It significantly complements the archaeological map of the late Bronze Age sites of the Black Sea region.
Victor Grebennikov
doaj  

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Polarization Holographic 4D Phenotyping Reveals Nanoplastic Induced Dysfunction in Zooplankton

Advanced Science, EarlyView.
Contaminant‐induced dysfunction in complex aquatic organisms remains difficult to resolve across scales. Polarization Holographic Imaging Microscopy (PHIM) integrates polarization‐sensitive holography with computational volumetric reconstruction for label‐free phenotyping of zooplankton in natural seawater, revealing that nanoplastic stress drives ...
Yuxing Li, Yanmin Zhu, Jingyan Chen, Rongzhou Chen, Yuen‐Wa Ho, Chutian Wang, James Kar‐Hei Fang, Kevin K. Tsia, Edmund Y. Lam   +8 more
wiley   +1 more source

Net-Impressed Pottery of Voznesenskoye I Settlement: from the late bronze age to the early iron age

Археология евразийских степей
The article introduces into scientific discourse the materials obtained during 2020 and 2022 excavations of the Voznesenskoye I settlement, a site of a multiple settling located in the surroundings of Lake Galichskoye.
Aleksandr V. Novikov
doaj   +1 more source

Childhood in Batina at the end of the late bronze age and the beginning of the early iron age [PDF]

Starinar
Batina is a multi-layered site situated on a prominent position above the Danube on Bansko Brdo in Baranja. This site holds particular significance for understanding the broader picture of settlement in the Middle Danube region during the Late ...
Ložnjak-Dizdar Daria, Rajić-Šikanjić Petra, Hulina Mateja, Dizdar Marko   +3 more
doaj   +1 more source