Results 71 to 80 of about 18,364 (316)

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

open access: yesAdvanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng   +17 more
wiley   +1 more source

Towards a fuller, more nuanced narrative of Chalcolithic and Early Bronze Age Britain 2500-1500 BC

open access: yes, 2008
This contribution considers some of the many recent advances in our understanding of Chalcolithic and Bronze Age Britain and uses these to highlight the weak points in our current state of knowledge.
Sheridan, J A, Sheridan, Alison
core  

Histories of deposition: creating chronologies for the Late Bronze Age-Early Iron Age transition in southern Britain [PDF]

open access: yes, 2019
The Late Bronze Age–Early Iron Age midden sites of Southern Britain are amongst the richest archaeological sites in the country. The organic accumulations contain substantial quantities of animal bone, decorated ceramics, metalwork and other objects; the
Bayliss, Alex   +12 more
core   +1 more source

Rescue Excavations of Bronze Age Barrows in Vetrino Region, northeast Bulgaria

open access: yesMateriale și Cercetări Arheologice, 2021
The aim of this study is to present the results of the rescue excavations of three Bronze Age barrows in Vetrino region, Northeast Bulgaria. Fourteen Early Bronze Age graves (4th– 3rd millennium BC), two of Middle Bronze Age date (first half of the 2nd ...
Alexandrov, S.   +2 more
doaj   +1 more source

Closed‐Loop Radiative Cooling Mulch Upcycled From Agricultural Residues for Efficient Soil Heat–Water Stress Mitigation

open access: yesAdvanced Science, EarlyView.
Conventional passive radiative cooling films rely on costly feedstocks and energy‐intensive fabrication, with poor end‐of‐life compatibility in agriculture. To address this challenge, a sustainable radiative cooling mulch (SRCM) is developed from waste maize leaves via spontaneous hydrogen‐bond self‐assembly.
Hao Li   +13 more
wiley   +1 more source

Influences of wood-crafting on technological development in Middle to Late Bronze Age Southern England

open access: yes, 2014
This study explores the relationship between wood-crafting activity and technological development in metal tools during the Late-Middle and Late Bronze Age in Southern England.
Lee, Robert William
core  

The Transjordanian Jordan Valley in the Late Bronze Age: under Egyptian control?

open access: yes, 2019
This chapter presents an overview scrutinizing the material evidence mainly from five sites in Transjordan in order to investigate the extent of Egyptian control over the Transjordanian Jordan Valley during the Late Bronze Age.
Fischer, Peter M.,, Peter M. Fischer
core   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang   +10 more
wiley   +1 more source

Descoperiri din perioada târzie a epocii bronzului de la Poieneşti, jud. Vaslui şi din Hallstattul timpuriu de la Scânteia, jud. Iaşi

open access: yesArheologia Moldovei, 2016
Late Bronze Age finds from Poieneşti (Vaslui County) and Early Hallstatt Finds from Scânteia (Iaşi County) Some Late Bronze Age finds (Noua culture) from Poieneşti, Vaslui County are discussed in the present article.
Cornelia-Magda Lazarovici   +1 more
doaj   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

open access: yesAdvanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung   +39 more
wiley   +1 more source

Home - About - Disclaimer - Privacy