Results 51 to 60 of about 5,136 (295)
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The world is changing: ethics and genre development in three twentieth-century high fantasies. [PDF]
This thesis examines three genre high fantasy texts published between 1954 and 2001: J. R. R. Tolkien’s 'The Lord of the Rings', Ursula K. Le Guin’s 'Earthsea' cycle and Patricia A. McKillip’s 'The Riddle-Master’s Game'.
Le Lievre, Kerrie Anne
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Blurring the lines between fantasy and reality : the cultural pervasiveness of The Lord of The Rings [PDF]
The Lord of the Rings, by J. R. R. Tolkien, is considered by many to be the definitive work of epic fantasy. Many critics have even gone as far as to declare Tolkien one of the primary authors of the Twentieth Century.
Cruise, Billy D. +1 more
core
J.R.R. TOLKIEN’S CONSTRUCTION OF MULTIPLE MASCULINITIES IN THE LORD OF THE RINGS
: The Lord of the Rings is one of the most widely acclaimed fantasy novels in history and since it was first published in the fifties, the analysis of the work from the perspective of gender has mainly focused on its female characters.
Beatriz Domínguez Ruiz
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
The Lord of the Rings : The return of the king [PDF]
A review of the third Lord of the Rings ...
Mills, Alice
core +1 more source
Intertextual Patterns in J.R.R.Tolkien‟s The Hobbit and The Lord of the Rings
The thesis that every text is a „mosaic of quotations‟ from other texts becomes particularly obvious when examining literary fantasy, which refers to the implied readers‟ previous reading rather than to real life.
Thomas Kullmann
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source

