Results 261 to 270 of about 629,141 (310)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Network analysis of meaning in life and depressive symptoms in Chinese adolescents. [PDF]

Medicine (Baltimore)
Wang X, Jiang N.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Development and Psychometric Properties of a Scale to Measure the Meaning of Life (MLS). [PDF]

Eur J Investig Health Psychol Educ
Guevara-Tantalean EA, Tantaleán-Arteaga AB, Arévalo-García BF, Cunza-Aranzábal DF.   +3 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Maximizing tendency and meaning in life: a cross-cultural network analysis of Chinese and American samples. [PDF]

BMC Psychol
Ma M, Deng J, Zhai S, Jia K, Sui J, Lin N, Wang M, Zhang L.   +7 more
europepmc   +1 more source

Mapping caregivers' distress: a network analysis of burden, meaning in life, and mental health in families facing suicidal behavior. [PDF]

Borderline Personal Disord Emot Dysregul
Pérez-Rodríguez S, Muñoz Rocha G, García-Alandete J, Guillén Botella V, Marco JH.   +4 more
europepmc   +1 more source

Meaning in life and Parkinson's disease: Evidence from a 17-year study across 14 countries. [PDF]

Arch Gerontol Geriatr
Karakose S, Terracciano A, Luchetti M, Stephan Y, Sutin AR.   +4 more
europepmc   +1 more source

The mediating role of death anxiety between meaning in life and spiritual care competence among Chinese nursing interns: implications for healthcare training. [PDF]

BMC Palliat Care
Zhang Z, Yang L, Zong X, Kardiyudiani NK, Han L, Xie R, Zhang R, Ma C.   +7 more
europepmc   +1 more source