Results 181 to 190 of about 126,794,803 (294)

Deciphering Residual Emissions: Time-dependent Models for the Nonthermal Interstellar Radiation from the Milky Way. [PDF]

Astrophys J, 2019
Porter TA, Jóhannesson G, Moskalenko IV.   +2 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Stellar performance: mechanisms underlying Milky Way orientation in dung beetles. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2017
Foster JJ, El Jundi B, Smolka J, Khaldy L, Nilsson DE, Byrne MJ, Dacke M.   +6 more
europepmc   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Origin of the Milky Way

, 1908
Postal que reproduce una pintura del año 1575 de Tintoretto. Representa a Júpiter, que deseando hacer inmortal a Hércules (cuya madre era el mortal Alcmene), lo sujetó a los pechos del Juno.
Anonymous
core  

The habitability of the Milky Way during the active phase of its central supermassive black hole. [PDF]

Sci Rep, 2017
Balbi A, Tombesi F.
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

The origin of the diverse morphologies and kinematics of Milky Way-mass galaxies in the FIRE-2 simulations. [PDF]

Mon Not R Astron Soc, 2018
Garrison-Kimmel S, Hopkins PF, Wetzel A, El-Badry K, Sanderson RE, Bullock JS, Ma X, van de Voort F, Hafen Z, Faucher-Giguère CA, Hayward CC, Quataert E, Kereš D, Boylan-Kolchin M.   +13 more
europepmc   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Signal coverage approach to the detection probability of hypothetical extraterrestrial emitters in the Milky Way. [PDF]

Sci Rep, 2017
Grimaldi C.
europepmc   +1 more source