Results 191 to 200 of about 3,556 (301)

A Milky Way-like barred spiral galaxy at a redshift of 3. [PDF]

Nature, 2023
Costantin L, Pérez-González PG, Guo Y, Buttitta C, Jogee S, Bagley MB, Barro G, Kartaltepe JS, Koekemoer AM, Cabello C, Corsini EM, Méndez-Abreu J, de la Vega A, Iyer KG, Bisigello L, Cheng Y, Morelli L, Arrabal Haro P, Buitrago F, Cooper MC, Dekel A, Dickinson M, Finkelstein SL, Giavalisco M, Holwerda BW, Huertas-Company M, Lucas RA, Papovich C, Pirzkal N, Seillé LM, Vega-Ferrero J, Wuyts S, Yung LYA.   +32 more
europepmc   +1 more source

Robust Amorphous MOF‐Based Aerogels Digital Biosensor for Sensitive Detection of Organophosphate Pesticides

Advanced Science, EarlyView.
We report a robust aerogel digital biosensor by integrating an enzyme‐mediated amorphous MOF within an aerogel matrix for on‐site pesticide detection. The enzyme‐mediated assembly strategy enables in situ tailoring of MOF into a porous amorphous structure, achieving both high stability and activity.
Changshun Su, Xiangyu Zhai, Houru Li, Yijie Wang, Hongxia Li, Yueyao Jiang, Geyu Lu, Xu Yan   +7 more
wiley   +1 more source

Study of physical properties of molecular clouds in the Milky Way Galaxy based on FUGIN datasets with machine learning

Study of physical properties of molecular clouds in the Milky Way Galaxy based on FUGIN datasets with machine learning
2022 この博士論文は内容の要約のみの公開（または一部非公開 ...
openaire   +1 more source

Unitary Entities Are the True "Atoms". [PDF]

Entropy (Basel)
Jeynes C, Parker MC.
europepmc   +1 more source

Dark matter substructure in the Milky Way

The standard Lambda-CDM cosmological model predicts a wealth of small-scale structures, including dark matter subhalos residing within more massive halos such as that of our own Milky Way galaxy. While some of these subhalos may be massive enough to host
Kong, Hyunsu
core   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

First submillimeter lights from Dome A: Tracing the carbon cycle in the feedback of massive stars. [PDF]

Sci Adv
Gong Y, Zhong J, Ren Y, Zhang Y, Liu D, Ao Y, Yao Q, Zhang W, Miao W, Lin Z, Duan W, Liu D, Zhou K, Liu J, Wang Z, Jin J, Zhang K, Wu F, Li J, Liu B, Zhang X, Luo Z, Wang J, Hao H, Lu X, Xie S, Quan J, Liu Y, Liang J, Deng X, Jiang J, Li L, Guo L, Ji T, Jiang P, Zhang Y, Shu C, Neupane S, Mao R, Shi S, Li J.   +40 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

The GD-1 Stellar Stream Perturber as a Core-collapsed Self-interacting Dark Matter Halo. [PDF]

Astrophys J Lett
Zhang X, Yu HB, Yang D, Nadler EO.
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source