Results 31 to 40 of about 3,556 (301)

Distributions and Physical Properties of Molecular Clouds in the G24 Region of the Milky Way

open access: yesThe Astronomical Journal
Abstract We report the spatial distribution and physical characteristics of molecular clouds in the G24 region, which is located near the intersection of the Milky Way’s Galactic bar with the Norma arm and the 3 kpc arm. Utilizing molecular line data from the Milky Way Imaging Scroll Painting project, including 12CO, 13CO and C18O, along
Tian Yang   +7 more
openaire   +3 more sources

An Out‐of‐Plane CO (J= 2–1) Survey of the Milky Way. II. Physical Conditions of Molecular Gas [PDF]

open access: yesThe Astrophysical Journal, 1997
Physical conditions of molecular gas in the first quadrant of the Galaxy are examined through comparison of the CO J = 2-1 data of the Tokyo-Nobeyama Radio Observatory survey with the CO J = 1-0 data of the Columbia survey. A gradient of the CO J = 2-1/J = 1-0 intensity ratio (≡ R2-1/1-0) with Galactocentric distance is reported.
Seiichi Sakamoto   +4 more
openaire   +1 more source

Is There a Disk of Satellites around the Milky Way? [PDF]

open access: yes, 2017
The "disk of satellites" (DoS) around the Milky Way is a highly debated topic with conflicting interpretations of observations and their theoretical models.
Yuexing Li   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

SF-R You Sure? The Conflicting Role of Star Formation Rates in Constraining the Evolution of Milky Way Analogs in Cosmological Simulations

open access: yesThe Astrophysical Journal
Milky Way analogs (MWAs) have long been studied by astronomers to place our Galaxy within an extragalactic context. With the power of cosmological simulations, we are now able to not only characterize MWAs today, but also watch as they evolve through ...
Alicia M. Savelli   +4 more
doaj   +1 more source

A Physical Interpretation of Milky Way Galaxy Dynamics from Precision Astrometrics

open access: yes, 2020
The dynamical and virial mass of the Milky Way galaxy is estimated using latest high precision stellar halo and dwarf galaxy satellite kinematics. The new data suggest the Galaxy is a highly compact, classically thermalized object. Kinematics exhibit significant velocity-spatial substructure, distinctive dynamic partitions, and strong Keplerian ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

What Is Missing from the Local Stellar Halo?

open access: yesThe Astrophysical Journal
The Milky Way’s stellar halo, which extends to >100 kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kiloparsecs of the Sun.
Katherine Sharpe   +2 more
doaj   +1 more source

The Milky Way is a Laboratory for New Ultra-long-baseline Neutrino Physics

open access: yesProceedings of 39th International Cosmic Ray Conference — PoS(ICRC2025)
8 pages, 3 figures; preliminary version of the proceedings for ...
Macdonald, Miller   +4 more
openaire   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

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