Results 61 to 70 of about 69,394 (286)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

DELVE Milky Way Satellite Galaxy Census. I. Satellite Population and Survey Selection Function in DES, DELVE, and Pan-STARRS

The Astrophysical Journal
The properties of Milky Way satellite galaxies have important implications for galaxy formation, reionization, and the fundamental physics of dark matter.
C. Y. Tan, A. Drlica-Wagner, A. B. Pace, W. Cerny, E. O. Nadler, A. Doliva-Dolinsky, D. Anbajagane, T. S. Li, J. D. Simon, A. K. Vivas, A. R. Walker, M. Adamów, K. Bechtol, J. L. Carlin, Q. O. Casey, C. Chang, A. Chaturvedi, T.-Y. Cheng, A. Chiti, Y. Choi, D. Crnojević, P. S. Ferguson, R. A. Gruendl, A. P. Ji, G. Limberg, G. E. Medina, B. Mutlu-Pakdil, N. E. D. Noël, K. Overdeck, V. M. Placco, A. H. Riley, D. J. Sand, J. Sharp, N. F. Sherman, G. S. Stringfellow, R. H. Wechsler, M. Aguena, S. Allam, O. Alves, D. Bacon, D. Brooks, D. L. Burke, R. Camilleri, J. A. Carballo-Bello, A. Carnero Rosell, J. Carretero, L. N. da Costa, M. E. da Silva Pereira, T. M. Davis, J. De Vicente, S. Desai, S. Everett, B. Flaugher, J. Frieman, J. García-Bellido, D. Gruen, G. Gutierrez, K. Herner, S. R. Hinton, D. L. Hollowood, D. J. James, K. Kuehn, O. Lahav, S. Lee, J. L. Marshall, C. E. Martínez-Vázquez, P. Massana, J. Mena-Fernández, R. Miquel, J. Muir, J. Myles, R. L. C. Ogando, A. A. Plazas Malagón, A. Porredon, E. Sanchez, D. Sanchez Cid, I. Sevilla-Noarbe, M. Smith, E. Suchyta, M. E. C. Swanson, C. To, E. J. Tollerud, D. L. Tucker, V. Vikram, N. Weaverdyck, M. Yamamoto, A. Zenteno, (DELVE and DES Collaborations)   +87 more
doaj   +1 more source

The nature of interstellar dust as revealed by light scattering

Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2011
Interstellar dust was first identified through the extinction that it causes of optical starlight. Initially, observational and theoretical studies of extinction were made to identify simple ways of removing the effect of extinction.
D. A. Williams
doaj   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Primary Period-Luminosity-Relation Calibrators in the Milky Way: Cepheids and RR Lyrae Physical basis, Calibration, and Applications

, 2023
In this invited review I discuss the calibration and applications of the period-luminosity relation of classical Cepheid and RR Lyrae stars. After a brief introduction, starting with results from Hipparcos and discussing some post-Hipparcos era developments, I focus on recent results using Gaia Data Release 3 data.
openaire   +2 more sources

Novel constraints on fermionic dark matter from galactic observables I: The Milky Way [PDF]

, 2018
We have recently introduced a new model for the distribution of dark matter (DM) in galaxies based on a self-gravitating system of massive fermions at finite temperatures, the Ruffini-Arg\"uelles-Rueda (RAR) model.
Argüelles, C. R., Krut, A., Rueda, J. A., Ruffini, R.   +3 more
core   +3 more sources

Smarter Sensors Through Machine Learning: Historical Insights and Emerging Trends across Sensor Technologies

Advanced Functional Materials, EarlyView.
This review highlights how machine learning (ML) algorithms are employed to enhance sensor performance, focusing on gas and physical sensors such as haptic and strain devices. By addressing current bottlenecks and enabling simultaneous improvement of multiple metrics, these approaches pave the way toward next‐generation, real‐world sensor applications.
Kichul Lee, Osman Gul, Yeongjae Kwon, Jaeseok Jeong, Seokjoo Cho, Jihyeon Ahn, Jehee Yu, Cheolmin Kim, Donho Lee, Hyeonseok Han, Byeongju Lee, Jungrak Choi, Ji‐Hwan Ha, Yongrok Jeong, Kyungnam Kang, Ali Javey, Junseong Ahn, Inkyu Park   +17 more
wiley   +1 more source

The Absolute Age of Milky Way Globular Clusters

The Astrophysical Journal
Globular clusters (GCs) provide statistically significant coeval populations of stars spanning various evolutionary stages, allowing robust constraints on stellar evolution model parameters and ages.
Jiaqi (Martin) Ying, Brian Chaboyer, Michael Boylan-Kolchin, Daniel R. Weisz, Rowan Goebel-Bain   +4 more
doaj   +1 more source

Revealing black holes with Gaia

, 2017
We estimate the population of black holes with luminous stellar companions (BH-LCs) in the Milky Way (MW) observable by Gaia. We evolve a realistic distribution of BH-LC progenitors from zero-age to the current epoch taking into account relevant physics,
Breivik, Katelyn, Chatterjee, Sourav, Larson, Shane L.   +2 more
core   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source