Results 31 to 40 of about 132,485,236 (247)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Bounds for the distance to the nearest correlation matrix [PDF]

, 2015
In a wide range of practical problems correlation matrices are formed in such a way that, while symmetry and a unit diagonal are ensured, they may lack semidefiniteness. We derive a variety of new upper bounds for the distance from an arbitrary symmetric
Higham, Nicholas, Higham, Nicholas J., Strabic, Natasa   +2 more
core   +6 more sources

Diffusion on PCA-UMAP Manifold: The Impact of Data Structure Preservation to Denoise High-Dimensional Single-Cell RNA Sequencing Data

Biology
Single-cell transcriptomics (scRNA-seq) is revolutionizing biological research, yet it faces challenges such as inefficient transcript capture and noise. To address these challenges, methods like neighbor averaging or graph diffusion are used.
Padron-Manrique Cristian, Vázquez-Jiménez Aarón, Esquivel-Hernandez Diego Armando, Martinez-Lopez Yoscelina Estrella, Neri-Rosario Daniel, Giron-Villalobos David, Mixcoha Edgar, Sánchez-Castañeda Jean Paul, Resendis-Antonio Osbaldo   +8 more
doaj   +1 more source

Unsupervised Transfer Learning via Relative Distance Comparisons

IEEE Access, 2020
Primitive machine learning method such as Support Vector Machine (SVM) or k-Nearest Neighbor (k-NN) faces a major challenge when its training and test data is distributed with large-scale variations in lighting conditions, color, backgrounds, size, etc ...
Rakesh Kumar Sanodiya, Leehter Yao
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Computing nearest stable matrix pairs [PDF]

, 2021
In this paper, we study the nearest stable matrix pair problem: given a square matrix pair (E,A), minimize the Frobenius norm of (∆E,∆A) such that (E+\∆E,A+∆A) is a stable matrix pair. We propose a reformulation of the problem with a simpler feasible set
Mehrmann, Volker, Sharma, Punit, Gillis, Nicolas   +2 more
core   +1 more source

Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging.

PLoS ONE, 2015
Nanoparticle uptake and distribution to solid tumors are limited by reticuloendothelial system systemic filtering and transport limitations induced by irregular intra-tumoral vascularization.
Christopher G England, Justin S Huang, Kurtis T James, Guandong Zhang, André M Gobin, Hermann B Frieboes   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

High-Efficiency Geographically Weighted Regression based on CUDA: an enhanced algorithm with adaptive kernel for investigating spatial non-stationarity in large-scale observations

International Journal of Digital Earth
Geographically Weighted Regression (GWR) enables local regression coefficients to vary at each point, thereby providing a more accurate depiction of variable relationships.
Yanchang Xu, Yi Yang, Hamed Karimian, Xiaochen Kang, Sensen Wu, Bo Huang   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source