Results 41 to 50 of about 132,485,236 (247)

A Novel Multi-Source Fault Diagnosis Strategy Based on Knowledge and Data Dual-Drive for a Planetary Gearbox

Sensors
Traditional fault diagnosis methods face challenges such as the insufficient utilization of fault information and an imbalance between classification accuracy and computation.
Hanzhi Yang, Jun Hao
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multiblock chemometric classification of commercial cigarettes sold in Brazil employing low-level data fusion of elemental, organic, and isotopic profiles

Results in Chemistry
Commercial cigarettes are chemically heterogeneous products whose fingerprints can reflect tobacco source, blend formulation, agronomic conditions, processing history, and manufacturing inputs. This study evaluated a multiplatform chemical-fingerprinting
Lucas Soares Rodrigues, Carlos German Massone, José Marcus de Oliveira Godoy   +2 more
doaj   +1 more source

Metabolite-disease interaction prediction based on logistic matrix factorization and local neighborhood constraints

Frontiers in Psychiatry, 2023
BackgroundIncreasing evidence indicates that metabolites are closely related to human diseases. Identifying disease-related metabolites is especially important for the diagnosis and treatment of disease.
Yongbiao Zhao, Yongbiao Zhao, Yuanyuan Ma, Qilin Zhang   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nearest neighbour distance matrix classification

, 2010
A distance based classification is one of the popular methods for classifying instances using a point-to-point distance based on the nearest neighbour or k-NEAREST NEIGHBOUR (k-NN).The representation of distance measure can be one of the various measures
Mohd Shamrie Sainin, Alfred, Rayner, Sainin, Mohd Shamrie, Rayner Alfred   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Bounds for the componentwise distance to the nearest singular matrix

, 1997
The normwise distance of a matrix A to the nearest singular matrix is well known to be equal to ∥A∥/cond(A) for norms subordinate to a vector norm. However, there is no hope for finding a similar formula or even a simple algorithm for computing the ...
Rump, Siegfried M.
core   +1 more source