Results 71 to 80 of about 1,590,388 (317)

Management of insomnia: update and new approaches

Nature and Science of Sleep, 2010
Insomnia is the most prevalent sleep disorder worldwide. A number of studies evaluated the efficacy of pharmacological and nonpharmacological treatment approaches. To obtain long-term effects in the management of chronic insomnia, cognitive-behavioral therapy for insomnia (CBT-I) is the treatment of first choice, encompassing education about sleep and ...
Thomas, Unbehaun, Kai, Spiegelhalder, Verena, Hirscher, Dieter, Riemann   +3 more
openaire   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Complex Edge of Talent Management: A cross-disciplinary approach

, 2013
The field of Human Resource Management (HRM) has traditionally been focused on conflict resolution to the detriment of positive factors. Because of this, HRM has a reputation for being negative, and is thus perceived quite negatively. This paper draws on
Chapman, Geoffrey, Gould, Ryan
core  

The risk approach to strategic management in development NGOs

, 2003
Today's rapid changes within and outside Northern and Southern NGOs heighten uncertainty about how to meet new challenges and achieve results. In this volatile environment, risk management is a tool for maximising an NGO's opportunities and minimising ...
Wilson-Grau, Ricardo
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Targeting the UCP1-dependent thermogenesis pathway with CRISPR/Cas9: a new approach to obesity management

Current Research in Biotechnology
Obesity is a complex, multifactorial disease characterized by excessive body fat accumulation, which negatively impacts health. Its increasing prevalence has led to a global epidemic, emphasizing the urgent need for innovative and effective treatment ...
Esmail Karami, Fatemeh Rostamkhani, Maasoume Abdollahi, Mohamadreza Ahmadifard   +3 more
doaj   +1 more source

Foodomics in Diabetes Management: A New Approach

Food Science & Nutrition
ABSTRACT Critical information regarding the interactions among food components, human metabolism, and disease is contained in foodomics, an interdisciplinary field that bridges food science with contemporary omics technologies (genomics, proteomics, metabolomics, and lipidomics).
Sammra Maqsood, Muhammad Tayyab Arshad, Ali Ikram, Hatem A. Al‐Aoh, Kodjo Théodore Gnedeka   +4 more
openaire   +2 more sources

A collaborative approach to design and delivery of a flipped classroom : a cross cultural management experience

, 2016
This paper explores a collaborative approach to the ongoing process of developing and delivering a flipped classroom teaching and learning design in an undergraduate cross cultural management unit in a Business Degree.
Kippist, Louise (R13516), Macmullen, Paul (R18971)   +1 more
core  

Overwriting New Public Management with New Public Governance in New Zealand's approach to health system improvement

, 2021
PurposeIn 2016, New Zealand's Ministry of Health introduced the System Level Measures Framework which marked a departure from health targets and pay-for-performance incentives towards an approach based on local, collaborative approaches to health system ...
Walton, Lisa, Silwal, Pushkar, Tenbensel, Tim   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source