Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Expression of Concern: Effects of climate change on niche shifts of Pseudotrapelus dhofarensis and Pseudotrapelus jensvindumi (Reptilia: Agamidae) in Western Asia. [PDF]
PLoS OnePLOS One Editors.
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Expression of Concern: The fate of endemic insects of the Andean region under the effect of global warming. [PDF]
PLoS OnePLOS One Editors.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Expression of Concern: Spatial abundance models and seasonal distribution for guanaco (Lama guanicoe) in central Tierra del Fuego, Argentina. [PDF]
PLoS OnePLOS One Editors.
europepmc +1 more source
One World; One Family; One Love
Journal of the Korean Academy of Child and Adolescent Psychiatry, 2020 openaire +3 more sources
1953 One Magazine Cover "Homosexual Marriage?"
, 1953 Color photograph front cover of the August 1953 issue of One Magazine Headline "Homosexual Marriage?
Mattachine Society
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Expression of Concern: Simulating impacts of rapid forest loss on population size, connectivity and genetic diversity of Sunda clouded leopards (Neofelis diardi) in Borneo. [PDF]
PLoS OnePLOS One Editors.
europepmc +1 more source