Results 141 to 150 of about 139,445,430 (292)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Correction: AKT inhibitors promote cell death in cervical cancer through disruption of MTOR signaling and glucose uptake

, 2014
The Plos One Staff
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Influenza: from zoonosis to pandemic

ERJ Open Research, 2016
Leslie A. Reperant, Fleur M. Moesker, Albert D.M.E. Osterhaus   +2 more
doaj   +1 more source

Role of tumor-associated macrophages (TAM) in modulating the tumor metabolism

, 2018
2
AHN, G ONE
core  

Investigating barriers & facilitators for the successful implementation of the BP@home initiative in London: primary care perspectives

Background The COVID-19 pandemic led to the implementation of a national policy of shielding to safeguard clinically vulnerable patients. To ensure consistent care for high-risk patients with hypertension, NHS England introduced the BP@home initiative to
Karki, Manisha, Sathaymoorthy, Ganesh, Majeed, Azeem, Kerr, Gabriele, El-Osta, Austen, Riboli-Sasco, Eva, El Asmar, Marie Line   +6 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Use of Intravenous Clonidine in Postoperative Pain Management: A Scoping Review. [PDF]

Acta Anaesthesiol Scand
Mohr T, Tsuchiya EA, Krag M, Dybdal B, Heiberg J.   +4 more
europepmc   +1 more source

One-to-one

Complexity, 1998
openaire   +2 more sources