Results 71 to 80 of about 65,226,620 (398)

Ecologically expanding the One Health framework to unify the microbiome sciences

mBio
The One Health framework, traditionally focused on microbial threats, needs a bold expansion to include the full breadth of microbial diversity—from pathogenic to beneficial—within its ecological and evolutionary context.
Nichole Ginnan, Sharifa G. Crandall, Madangchanok Imchen, Francisco Dini-Andreote, Tim I. Miyashiro, Vishal Singh, Erika Ganda, Seth R. Bordenstein   +7 more
doaj   +1 more source

Cytokine profiles in early rejection following OKT3 treatment in liver transplant patients

Mediators of Inflammation, 2000
OKT3, a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFα and IL1β.
Sasan Roayaie, Patricia A. Sheiner, Sukru Emre, Steven Guy, Myron E. Schwartz, Peter Boros, Charles M. Miller   +6 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Parental Occupation and the Gender Math Gap: Examining the Social Reproduction of Academic Advantage among Elementary and Middle School Students

Social Sciences, 2017
Math proficiency is considered a critical subject for entry into most science, technology, engineering, and math (STEM) occupations. This study examines the relationship between parental occupation and gender differences in students’ math performance ...
Monica Bowden, John P. Bartkowski, Xiaohe Xu, Richard Lewis Jr.   +3 more
doaj   +1 more source

Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer

Cells, 2023
Indoleamine 2,3-dioxygenase 2 (IDO2) is a tryptophan-catabolizing enzyme and a homolog of IDO1 with a distinct expression pattern compared with IDO1. In dendritic cells (DCs), IDO activity and the resulting changes in tryptophan level regulate T-cell ...
Sarah Y. Kado, Keith Bein, Alejandro R. Castaneda, Arshia A. Pouraryan, Nicole Garrity, Yasuhiro Ishihara, Andrea Rossi, Thomas Haarmann-Stemmann, Colleen A. Sweeney, Christoph F. A. Vogel   +9 more
doaj   +1 more source

The People as One Malala [PDF]

, 2016
Third ...
Tavares, Ariel
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Novel Ent-Kaurene Glycosides with Eight Glycosyl Units from

Natural Product Communications, 2018
Several steviol glycosides from Stevia rebaudiana are associated with extremely potent sweetness and are sought-after as low-calorie alternatives to sucrose.
Indra Prakash, Bin Wang, Gil Ma, George Harrigan, Steven F. Sukits, Krishna P. Devkota, Romila D. Charan, Ryan Donovan, Tara M. Snyder   +8 more
doaj   +1 more source

Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples

BMC Bioinformatics, 2018
Background Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively neutral (passenger) mutations.
Ivan P. Gorlov, Claudio W. Pikielny, Hildreth R. Frost, Stephanie C. Her, Michael D. Cole, Samuel D. Strohbehn, David Wallace-Bradley, Marek Kimmel, Olga Y. Gorlova, Christopher I. Amos   +9 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source