Results 141 to 150 of about 10,385,733 (292)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Status and influencing factors of obstetric violence: a mixed study

BMC Public Health
Background Few researches have focused on obstetric violence in the Asia-Pacific region, necessitating an understanding of the current situation of obstetric violence and exploration of factors influencing its occurrence.
Shan Huang, Meihui Li, Mingyang Zhang, Wenjun Zhang, Xueyan Wang, Wenting Yang, Jing Zhang, Jinguo Zhai   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The effect of micro-movement on prevention of intraoperative acquired pressure injury in overweight patients undergoing posterior lumbar surgery: a randomized controlled trial

Journal of Orthopaedic Surgery and Research
Background In posterior lumbar surgery, overweight patients are more prone to intraoperative acquired pressure injury (IAPI) due to bleeding, longer operative time, and increased pressure. The current prevention strategies have limited effects.
Jing Zhang, Ping Wang, Li En Qi, Shuo Feng, Feng Zhang   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Topology of Conflict and Co-operation [PDF]

The class of simultaneous 2x2 pure-strategy ordinal games (which include well-known games such as Prisoner’s Dilemma, Chicken and Stag Hunt) have received considerable attention, including complete classification schemes by amongst others Rapoport ...
Sam Perlo-Freeman
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Idiosyncratic Values of IT-enabled Agility at the Operation and Strategic Levels

Communications of the Association for Information Systems, 2016
O. Lee, Peng Xu, Jean-Pierre Kuilboer, Noushin Ashrafi   +3 more
semanticscholar   +1 more source

Stabilization and operation of a Kerr-cat qubit

Nature, 2020
A. Grimm, N. Frattini, S. Puri, S. Mundhada, S. Touzard, M. Mirrahimi, S. Girvin, Shyam Shankar, Shyam Shankar, M. Devoret   +9 more
semanticscholar   +1 more source