Results 101 to 110 of about 134,171,610 (311)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Actual questions of clinical pharmacology by amlodipine: should we prefer the original or a generic drug?

open access: yesКардиоСоматика, 2016
Selection of amlodipine (tablets) as a drug based on three basic criteria: clinical efficacy, safety / tolerability and quality is discussed below. The article deals with the successive stages of clinical pharmacology and pharmacotherapy from amlodipine ...
A. S Dukhanin
doaj  

Pharmaceutical development specifics of new generic drug products in suspension for injection form on the Betaspan depot (Depos) example

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
The range of combined domestic drug products in suspension for injections form with a specific purpose for the topical treatment of rheumatoid arthritis is limited, and available drug products are mainly submitted by foreign companies and their number ...
O. I. Kachaput   +2 more
doaj   +1 more source

Comparative Study of Drug Efficacy and Drug Additives between Generic Drugs and Original Drugs

open access: yesYAKUGAKU ZASSHI, 2007
In the present study, we tested three kinds of sleeping drugs, consisting mainly of triazolam, brotizolam, and flunitrazepam, to compare the drug efficacy of generic drugs with that of original drugs. After these drugs were administered orally to mice, drug efficacy was evaluated in terms of ambulation, onset time of sleep, and duration of sleep in the
Hiromi, Katoh   +2 more
openaire   +3 more sources

The effectiveness of court appointed drug education. [PDF]

open access: yes, 2007
Crosscare Drug & Alcohol Programme (DAP) commissioned this research to review the effectiveness of court appointed drug education from the perspective of the voluntary sector. Allied Irish Bank’s Better Ireland Programme kindly provided the funding.
Giaquinto, Fran
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National Campaign Against Drug Abuse Social Issues Survey, 1988

open access: yes, 2018
Since 1985, as part of the National Campaign Against Drug Abuse, substantial survey research has been undertaken to assess the extent of drug problems, the effectiveness of interventions, and the impact of aspects of the campaign.
Drugs of Dependence Branch, National Drug Abuse Information Centre
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Rethinking the "drug dealer". [PDF]

open access: yes, 2019
Policymakers in the United States increasingly recognize that drug use should be treated as a public health issue instead of a criminal issue. Most, however, continue to support harsh criminal sentences for people who are involved with drug selling or ...

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

The global drug survey 2015

open access: yes, 2015
This survey attracted more than 100,000 on line responses from individuals around the world about their drug use. The study looked at prevalence, price, purity, value for money and the proportion of people seeking medical treatment.
Global Drug Survey
core  

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