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Model Master File Framework: A Regulatory Path Advancing Modeling and Simulation Applications [PDF]
Clinical and Translational ScienceTo advance drug product development, regulatory decision making, and improve patient care, FDA has committed to the quantitative medicine paradigm that involves, among others, quantitative in silico methodologies and tools developed based on nonclinical,
Eleftheria Tsakalozou +4 more
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UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion [PDF]
PeerJ, 2023 Background Icaritin (ICT) has been previously demonstrated to display protective effects against cerebral ischemic reperfusion (I/R) by inhibiting oxidative stress, but the mechanism remains unclear.
Yunfeng Tang +7 more
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Journal of Dual Diagnosis, 2021 I am grateful to my colleague and friend, Editor-in-Chief Sherwood Brown, for this opportunity to extoll Dr. Alan Green, MD (1953–2020) as a humanitarian and as a clinician scientist.
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Pharmacological Research - Modern Chinese Medicine, 2022 Mastitis is the most common malignant disease in women, which seriously threatens women's physical and mental health. Jingfang Granules (JF) is a Chinese medicine compound, derived from the classic famous prescription-''Jingfang Baidu Powder''.
ShiRong Li +10 more
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Perception of generic drugs among residents in a district of Peru [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: In the Peruvian context, generic drugs are those pharmaceutical products whose names correspond to the active ingredient of the drug and are not identified by a brand name; brand name drugs, on the other hand, are pharmaceutical products whose ...
Ambrocio Teodoro Esteves Pairazaman +4 more
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Frontiers in Immunology, 2022 With the rapid aging of the population, the control of age-related disease susceptibility and prognosis faces greater challenges. There is an urgent need for a strategy to maintain the vitality of elderly people.
Qin Feng +7 more
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Generating generic functions [PDF]
Proceedings of the 2006 ACM SIGPLAN workshop on Generic programming, 2006 We present an approach to the generation of generic functions from user-provided specifications. The specifications consist of the type of a generic function, examples of instances that it should "match" when specialized, and properties that the generic function should satisfy.
Jeuring, J.T. +2 more
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MS/MS-Based Molecular Networking: An Efficient Approach for Natural Products Dereplication
Molecules, 2022 Natural products (NPs) have historically played a primary role in the discovery of small-molecule drugs. However, due to the advent of other methodologies and the drawbacks of NPs, the pharmaceutical industry has largely declined in interest regarding ...
Guo-Fei Qin +9 more
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CPT: Pharmacometrics & Systems Pharmacology, 2022 The coronavirus disease 2019 (COVID‐19) has presented unprecedented challenges to the generic drug development, including interruptions in bioequivalence (BE) studies.
Yuqing Gong +12 more
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Generic evolutionary design [PDF]
Generic evolutionary design means the creation of a range of different designs by evolution. This paper introduces generic evolutionary design by a computer, describing a system capable of the evolution of a wide range of solid object designs from ...
Wakefield, Jonathan P. +1 more
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