Results 41 to 50 of about 828,807 (306)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A comparative analysis of the microbiome of cigars produced in the Caribbean and China

Scientific Reports
Fermentation of cigar tobacco leaves involves intense microbial activity, and hence, microorganisms have a significant impact on the quality and flavour of cigars. However, research on the correlation between microbial communities and the sensory quality
Bo Ding, Yuan Ji, Xiaojie Xu, Xiaokang Cui, Xiaoli Meng, Zhen Shen, Lihong Ren, Yinghui Guo, Sheng Xing, Shili Liu, Min Liu   +10 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Generating functions for generating trees

Discrete Mathematics, 2002
This article corresponds, up to minor typo corrections, to the article submitted to Discrete Mathematics (Elsevier) in Nov. 1999, and published in its vol. 246(1-3), March 2002, pp.
Banderier, Cyril, Flajolet, Philippe, Gardy, Danièle, Bousquet-Mélou, Mireille, Denise, Alain, Gouyou-Beauchamps, Dominique   +5 more
openaire   +6 more sources

The Many Faces of Glimepiride: on the Question of Interchangeability of Oral Hypoglycemic Agents

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
The article presents a literature review on the use of glimepiride while treating patients with diabetes mellitus. Characteristics of generic drugs of glimepiride are provided.
N.V. Bezdetko
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Little pro’s, but how many of them? – On 3SG null pronominals in Hungarian

LingBaW, 2017
While Hungarian 3SG individual reference null pronominals are in free variation with their lexical counterparts, 3SG generic reference null pronominals do not show such variation.
Gréte Dalmi
doaj   +1 more source

GENERALIZED SPACES OF GENERAL RELATIVITY [PDF]

Proceedings of the National Academy of Sciences, 1959
1. This paper is a revision of the paper with the same title which was published a year ago. The paper deals with a space of four dimensions V4 of coordinates xi as i takes the values 1 to 4. The geometry of the space is based upon the asymmetric functions gij and the asymmetric coefficients of connection Prk and upon the Einsteinm equation2 gij,k ...
openaire   +2 more sources