Results 141 to 150 of about 134,171,610 (311)

Toxicities of docetaxel: original drug versus generics-a comparative study about 81 cases. [PDF]

Springerplus, 2016
Elm'hadi C, Tanz R, Khmamouche MR, Toreis M, Mahfoud T, Slimani KA, Errihani H, Ichou M.   +7 more
europepmc   +1 more source

Queensland Drug Trends 2024: Key Findings from the Illicit Drug Reporting System (IDRS) Interviews [PDF]

The Illicit Drug Reporting System (IDRS) is a monitoring system identifying trends in illicit drug markets that has been conducted in all capital cities of Australia since 2000.
Daly, Catherine, Salom, Caroline, Thomas, Natalie, Juckel, Jennifer, Barber, Tayla   +4 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease [Corrigendum]

Drug Design, Development and Therapy, 2015
Bennett LL, Turcotte K. Drug Des Devel Ther. 2015;9:4639–4647.On page 4642, left column, 2nd word, the drug name Cardelga® should have been Cerdelga®.On page 4643, Table 2, the drug name Cardelga® should have been Cerdelga®.Read the
Bennett LL, Turcotte K
doaj  

Queensland Drug Trends 2025: Key Findings from the Illicit Drug Reporting System (IDRS) Interviews

The Illicit Drug Reporting System (IDRS) is a national illicit drug monitoring system that has been conducted annually since 2000 and is part of  Drug Trends. This 2025 IDRS report provides the most up-to-date findings of the IDRS interviews from 2000 to
Daly, Catherine, Salom, Caroline, Thomas, Natalie, Uporova, Julia, Sutherland, Rachel ; https://orcid.org/, Juckel, Jennifer, Barber, Tayla   +6 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Lynn Ruane: Drug courts are not the solution to Ireland's drug problem.

, 2019
We cannot have a National Drug Strategy that prefers the drug court to a health-focused approach.....
Ruane, Lynn
core