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The Origin of Antithyroid Drugs
Thyroid®, 2023Background: When the antithyroid drugs were discovered in the early 1940s, they were immediately recognized as a revolutionary new treatment for hyperthyroidism. Although much has been learned about their mechanism of action and clinical utility, they continue to be used today in much the same way as they have ...
Clark T, Sawin, David S, Cooper
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The genetic origin of responses to drugs
British Medical Bulletin, 1995Individual variation in drug metabolism has been extensively investigated. Population studies have shown that there is a wide range in metabolising ability for all detoxification pathways; the distributions may be unimodal (Gaussian) or polymodal, with subsets of individuals who differ from the majority. These may be poor metabolisers (PM) or extensive
R H, Waring, P, Emery
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The origins of antimalarial drug resistance
Trends in Parasitology, 2004Resistance of Plasmodium falciparum to the antimalarial drug sulfadoxine-pyrimethamine is a result of extremely rare mutations that have spread over large geographical areas. This pattern was completely unexpected because mutations encoding resistance occur commonly in laboratory conditions, leading to the expectation that resistance would originate ...
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2021
This chapter recounts how human ancestors chewed tree bark and drank herbal tea to relieve their illnesses, whereas today people are more likely to visit the doctor and take prescribed medication. Modern medication generally appears in tablet or capsule form, and the active ingredient will have first appeared in pure form on a chemist's bench.
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This chapter recounts how human ancestors chewed tree bark and drank herbal tea to relieve their illnesses, whereas today people are more likely to visit the doctor and take prescribed medication. Modern medication generally appears in tablet or capsule form, and the active ingredient will have first appeared in pure form on a chemist's bench.
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On the origins of drug polypharmacology
MedChemComm, 2013The ability of many drugs, unintended most often, to interact with multiple proteins is commonly referred to as polypharmacology. Could this be a reminiscent chemical signature of early protein evolution?
Xavier Jalencas, Jordi Mestres
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2012
A brief history of the discovery and invention of a selection of drugs is provided as an introduction to this textbook on clinical trials. Examples were chosen from drugs that are classified as natural products, analogues of naturallyoccurring metabolites, antibodies, and drugs identified by screening libraries of chemicals. Also, as an introduction to
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A brief history of the discovery and invention of a selection of drugs is provided as an introduction to this textbook on clinical trials. Examples were chosen from drugs that are classified as natural products, analogues of naturallyoccurring metabolites, antibodies, and drugs identified by screening libraries of chemicals. Also, as an introduction to
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The Origins of Antimalarial-Drug Resistance
New England Journal of Medicine, 2014There is a tendency to view the development of antimalarial-drug resistance as an inevitable outcome of the drugs' widespread use. Yet resistance has been accelerated by the way the drugs are used and by the social and economic conditions in which they are used.
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Plants of Indian origin in drug discovery
Expert Opinion on Drug Discovery, 2007The Indian system of medicine (ISM) consists of several major components such as Ayurveda, Siddha, Unani and homeopathy. All these components provide the major healthcare for a large part of the population in India and have been flourishing in this country for many centuries. Medicinal plants constitute a major part in all of these traditional systems.
Mukherjee, PK +5 more
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Drug molecules of marine origin
1990Somewhat accelerated developments in the chemistry and pharmacology of marine molecules during the eighties are a clear indication of the biomedical potential of marine organisms for the twenty-first century. Unfortunately, the overall effort toward the field is still insignificant.
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Analytical aspects of drugs of natural origin
Journal of Pharmaceutical and Biomedical Analysis, 1989The current importance of drugs of natural origin and their different phytotherapeutical preparations are mentioned. Analytical aspects related to vegetable drugs and their extracts are discussed. An overview is given on procedures used for the isolation of reference compounds, sample preparation for high-performance liquid chromatographic analysis ...
Hamburger M, Hostettmann K
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