Results 101 to 110 of about 128,240,371 (320)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Impact of nutritional status and abnormal bone–muscle metabolism on chronic low back pain after lumbar decompression surgery: a multicenter predictive model study based on paraspinal muscle parameters

Frontiers in Nutrition
ObjectiveThis study aimed to investigate the associations of preoperative nutritional status, bone–muscle metabolic abnormalities, and paraspinal muscle degeneration with chronic low back pain (CLBP) after lumbar decompression surgery.
Shihao Zhou, Shihao Zhou, Zhenqian Qi, Zhenqian Qi, Xiaowan Xu, Hongshun Zhao, Junhao Sun, Tianluo Guo, Tianluo Guo, Peiran Hu, Peiran Hu, Xin Zhou, Xiaolong Jia, Xudong Yan, Zhihua Xu, Hongxing Shan, Huiqiang Zhao, Lu Miao, Shuai Ma, Shuai Ma, Bin Yuan, Hengji Li, Guilan Gou, Chao Zhu, Dazhi Yang, Junhua Tian, Yajun Deng, Jiancuo A   +27 more
doaj   +1 more source

Dignity's Dilemma: Categorical Objections to Autonomous Weapons and Their Pacifist Entailments

Journal of Applied Philosophy, EarlyView.
ABSTRACT Dignity objections to autonomous weapon systems are prominent in contemporary military ethics, yet their theoretical foundations remain underexamined. This article reconstructs those foundations, showing what categorical dignity objections require to function as absolute prohibitions.
Timothy Dubber
wiley   +1 more source

Performative Blame Avoidance

Journal of Applied Philosophy, EarlyView.
ABSTRACT Sometimes we avoid or minimize criticism for our failings by performing a merely symbolic act aimed at addressing a real or perceived blame allegation. Consider individuals or institutions performing land acknowledgements as a means of box‐ticking inclusion without committing to any significant change. Or consider corporations forming advisory
Nicolas Nicola
wiley   +1 more source

Formation of the system of political education in the Red Army after the October Revolution of 1917

The ivanovo state university bulletin Series "The Humanities", 2023
A. Shmakov, A. Abidulin
semanticscholar   +1 more source

Preliminary Development and Assessment of a Multiplex Assay for Human Papillomavirus Antibody Detection Using Commercial L1 Proteins

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed and assessed a new multiplex assay for the simultaneous detection of antibodies against multiple Human Papillomavirus (HPV) types. Using recombinant L1 protein, the assay quantifies IgG and IgA responses in human plasma, enabling comprehensive immune profiling across multiple high‐risk cancer‐associated HPV genotypes. This approach
Arash Aslanabadi, Maryam Karimi, Laura Powell, Lisa Schumaker, Ashley Shutt, Mahsa Hojabri, Rahim Abbasi, Søren M. Bentzen, Kevin J. Cullen, Trevor A. Crowell, Rebecca G. Nowak, Mohammad M. Sajadi   +11 more
wiley   +1 more source

Late Holocene environmental history of Dojran, Macedonia: Investigating the interplay of imperial dynamics and climatic change

Journal of Quaternary Science, EarlyView.
ABSTRACT This study presents a high‐resolution, multi‐proxy reconstruction of environmental and land‐use change from Lake Dojran over historical times (last 2500 years), combining pollen, biomarkers, radiocarbon dating, Ottoman taxation records and other historical data.
Alessia Masi, Lucrezia Masci, Georgios C. Liakopoulos, Monica Bini, Alexander Francke, Ilaria Isola, Carlo Ricotta, Laura Sadori, Alexander Sarantis, Sławomir Sprawski, Jakub Sypiański, Irene Tunno, Cristiano Vignola, Bernd Wagner, Giovanni Zanchetta, Adam Izdebski   +15 more
wiley   +1 more source

Models of DG‐Carbon Bands in Raman Spectra: Effects of Basis Functions and Initial Values on the Uniqueness and S/N of Fits Obtained for Atmospheric Aerosol Using Automated Methods

Journal of Raman Spectroscopy, EarlyView.
Raman spectra containing D/G features are fit using combinations of basis functions and initial conditions. Fits with two Lorentzian functions converged to a single optimized fit even with variation of initial peak positions. For five‐band fits, sometimes the final fit varied with initial conditions, and constraints on peak center position were ...
David C. Doughty, Steven C. Hill
wiley   +1 more source