Results 71 to 80 of about 881,359 (300)

Predicting Failure using Conditioning on Damage History: Demonstration on Percolation and Hierarchical Fiber Bundles

, 2005
We formulate the problem of probabilistic predictions of global failure in the simplest possible model based on site percolation and on one of the simplest model of time-dependent rupture, a hierarchical fiber bundle model.
D. Sornette, D. Sornette, D. Sornette, D. Stauffer, G. Grimmett, J. V. Andersen, P. Shebalin, V. I. Keilis-Borok   +7 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Environmental public good provision under robust decision making [PDF]

, 2016
We study public good provision in a two-country dynamic setup with environmental externalities. In this framework, we examine robust decision making under potential misspecification of the process that describes the evolution of the environmental ...
Angelopoulos, Konstantinos, Economides, George, Philippopoulos, Apostolis   +2 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Parameter Estimation and Sensitivity Analysis of an Optimal Control Model for Capital Asset Management

Advances in Fuzzy Systems, 2018
Optimal control is a very significant field of modern control theory which has been applied in many areas like medicine, science, and finance. This work is based on realization of asset values as a benefit of asset management where a capital asset ...
Tolulope Latunde, Olabode Matthias Bamigbola   +1 more
doaj   +1 more source

Trajectory Tracking Control of Underwater Vehicle-Manipulator System Using Discrete Time Delay Estimation

IEEE Access, 2017
A new nonlinear robust control scheme is proposed and investigated for the trajectory tracking control problem of an underwater vehicle-manipulator system (UVMS) using the discrete time delay estimation (DTDE) technique.
Yaoyao Wang, Surong Jiang, Bai Chen, Hongtao Wu   +3 more
doaj   +1 more source

Regulation of Stochastic Fisheries: A Comparison of Alternative Methods in the Pacific Halibut Fishery [PDF]

This article considers the relative merits of ad valorem taxation, season controls, and entry limitation as methods the government may use to deal with the externality problem in the Pacific halibut fishery.
Androkovich, Robert A., Stollery, Kenneth R.   +1 more
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Expanding N-glycopeptide identifications by modeling fragmentation, elution, and glycome connectivity

Nature Communications
Accurate glycopeptide identification in mass spectrometry-based glycoproteomics is a challenging problem at scale. Recent innovation has been made in increasing the scope and accuracy of glycopeptide identifications, with more precise uncertainty ...
Joshua Klein, Luis Carvalho, Joseph Zaia
doaj   +1 more source