Results 91 to 100 of about 136,147 (300)
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
The Voluntary Right to Buy pilot: Additional analysis of completions
, 2017 This report builds on detailed analysis of the lessons from the pilot programme for the Voluntary Right to Buy (VRTB). The introduction of the right to buy (RTB) for eligible tenants in specified housing association dwellings was a manifesto commitment ...
Reeve, Kesia, Pattison, Ben, Cole, Ian
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ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
‘The Right to Housing: A Research Agenda’
, 2019 Housing provides and protects some of our most fundamental needs. It shields us from the elements and provides refuge from external physical threats.
Hohmann, J
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source
A Critique of the Housing Production Leap Act With Emphasis on Its Implementation Regarding University Properties and Lands in Light of Judicial Procedure [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒UmūmīIntroductionAccording to Article (31) of the Constitution of the Islamic Republic of Iran, access to adequate housing is the right of every Iranian individual and family; the government is obliged to make this right a reality, with priority given to ...
Mahin Sobhani +2 more
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
The 2007/2008 global financial crisis severely affected EU semi-peripheral countries like Spain, where recovery policies facilitated the entry of international financial actors into the real estate market. In Spain, measures by the state and central bank
D'adda, Gabriele, Rossini, Luisa
core +1 more source