Results 51 to 60 of about 136,147 (300)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

De la relégation à l’appropriation : (re)lire la citadinité à Khartoum au prisme de la transformation matérielle, sociale et symbolique de ses périphéries

EchoGéo
In the context of the ongoing conflict in Sudan since April 2023, this article proposes to analyse the citadinities that have been constructed on the outskirts of Khartoum over the last two decades.
Corten Pérez-Houis, Alice Franck
doaj   +1 more source

Thatcherite ideology, housing tenure, and crime: the socio-spatial consequences of the right to buy for domestic property crime [PDF]

, 2015
Our aim in this article is to explore the degree to which the changes produced in the provision of housing in England and Wales produced changes in the socio-spatial distribution of economic need and social deprivation, which in turn changed the ...
Colin Hay, Will Jennings, Hay, Colin, Farrall, Stephen, Jennings, Will, Jennings, W., Stephen Farrall, Hay, C., Gray, Emily, Gray, E., Farrall, S., Emily Gray   +11 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Making sense of place-making in Penang island’s affordable housing schemes: voices from key stakeholders

International Journal of Urban Sustainable Development, 2020
The housing agenda shifted its paradigm from housing as basic needs to housing as rights. It became widely contested when ‘affordable housing’ entered the discourse.
Suet Leng Khoo, Kuan Heong Woo
doaj   +1 more source

Redrawing the border through the 'Right to Rent': exclusion, discrimination and hostility in the English housing market [PDF]

, 2019
The UK Immigration Act 2016 is central to the Conservative Government’s drive to create a more hostile environment for potential migrants and current ‘illegal’ migrants residing in the UK.
Tokarczyk, Trudi, Crawford, Joe, Leahy, Sharon, McKee, Kim, Crawford, Joseph   +4 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Self-build in the UK and Netherlands:mainstreaming self-development to address housing shortages? [PDF]

, 2015
This paper examines approaches to self or custom-build in the Netherlands and the UK to offer comparative insights into self- and custom-built housing contexts and cultures, and specifically, the relationships with local and strategic planning ...
Lloyd, M.G., L.B. Janssen-Jansen, M.G. Lloyd, Lloyd, M. G., Janssen-Jansen, L. B., Peel, D., Janssen-Jansen, Leonie, Janssen-Jansen, L.B., D. Peel   +8 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The ratification of the international covenant on economic, social and cultural rights, strategic litigation and the right of access to adequate housing [PDF]

, 2018
Magister Legum - LLMAccess to adequate housing is an important socio-economic right and is of central importance for the enjoyment of all rights. The right to access adequate housing is viewed as a fundamental human right and has been described in both ...
Rippenaar, Shéan Jamie
core   +1 more source