Results 51 to 60 of about 41,270 (311)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Constrained optimization in simulation: a novel approach. [PDF]
This paper presents a novel heuristic for constrained optimization of random computer simulation models, in which one of the simulation outputs is selected as the objective to be minimized while the other outputs need to satisfy prespeci¯ed target values.
Van Nieuwenhuyse, Inneke +2 more
core +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
AN OPTIMIZING UP-AND-DOWN DESIGN
, 2016 Assume that the probability of success is unimodal as function of dose. Take the response to be binary and the possible treatment space to be a lattice. The Optimizing Up-and-Down Design allocates treatments to pairs of subjects in a way that causes the ...
Euloge E. Kpamegan (16760022) +1 more
core +1 more source
Fatigue Analysis of Actuators with Teflon Impregnated Coating—Challenges in Numerical Simulation
Actuators, 2021 Actuators are essential components for motion in machines, and warranty service lives are basic specifications of actuators. However, fatigue damage or wear of actuators are very complex and related to many design factors, such as materials properties ...
Zhuming Bi, Bongsu Kang, Puren Ouyang
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The simulation-based method of evaluating and optimizing experiment designs.
, 2020 Note: light-blue elements denote required user inputs. (A) Dataset simulation process generates experiment realizations (e.g., cue-outcome sequences) and model responses (e.g., predicted physiological or behavioral responses), which together form a ...
Dominik R. Bach (7865564) +1 more
core +1 more source
MathematicsDue to their improved performance and advantages for the environment, fuel cell hybrid electric cars, or FCEVs, have garnered a lot of attention. Establishing an energy management strategy (EMS) for fuel cell electric vehicles (FCEVs) is essential for ...
Houssam Eddine Ghadbane +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source