Results 41 to 50 of about 409,268 (262)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

University proceedings. Volga region. Technical sciences

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. The purpose of the research is to develop a computer model for optimizing the loading of machines of the same classification group, but of different types, of the existing fleet of technological equipment of the enterprise.
V.V. Konovalov, M.V. Dontsova, A.N. Rasstegaev, V.Yu. Zaitsev   +3 more
doaj   +1 more source

Tubuloside B ameliorates blood-brain barrier disruption and cognitive deficits after cerebral ischemia by inhibiting TRIC protein ubiquitination and degradation

Journal of Neuroinflammation
Background and purpose Vascular cognitive impairment (VCI) is strongly linked to blood-brain barrier (BBB) dysfunction. This study investigated whether Tubuloside B (Tub-B), a primary bioactive compound of Cistanche tubulosa, ameliorates cognitive ...
Mingli He, Han Zhang, Ru Liu, Chunyang Zhang, Juan Li, Luming Li, Liang Li, Hao Yang, Qiu Liu   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Digital control over the working process – technological and legal aspects [PDF]

Икономика и компютърни науки, 2020
The purpose of this article is to examine two main aspects of the control over the working process – technological and legal. In their interconnection they reflect the new means, through which the employers perform their functions on management and ...
Andriyana Andreeva, Oleg Asenov
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Technological Process of Forging Blank Camshaft

Scientific Journal of Gdynia Maritime University, 2017
The article presents technological process of forging blank camshafts. It describes materials used on the camshafts blanks. The paper also sets out the conditions for the selection of manufacturing technology of semi-finished products.
K. Panasiuk
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Prospects for modernization of technological machine tools in the format of the Industry 4.0 concept

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. Digital transformation creates opportunities for the transition of industry to a new level of production, but requires the modernization of technological equipment to a digital technological system.
Yu.L. Chigirinskiy, D.V. Kraynev, Zh.S. Tikhonova, E.M. Frolov   +3 more
doaj   +1 more source

Acoustics aspects of technological process in the rock disintegration [PDF]

Acta Montanistica Slovaca, 2007
The paper describes some results of monitoring and aspects of the acoustic signal in the rock disintegration on the drillig stand of the Institute of Geotechnics, SAS in Košice.
Jozef Futó, František Krepelka
doaj