Results 71 to 80 of about 2,388,857 (262)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The Just War Tradition and Natural Law [PDF]
, 2004 This Essay is divided into three parts. First, it briefly discusses Augustine on the notion of a naturalistic morality implanted in human minds and hearts. Second, it traces the ways in which such notions as human nature figure in Augustinian and post-
Elshtain, Jean Bethke
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Ученые записки Казанского университета: Серия Гуманитарные науки, 2017 The paper focuses on the functioning of the hagiographic tradition in the works of Yu. Kazakov, a Russian writer of the second half of the 20th century. In the review of the available studies, an active interest in the reception of Old Russian literature
N.G. Mahinina, M.M. Sidorova
doaj
Politeja, 2018 Christian Conservatism. Selected Theological Aspects in the Works of Metropolitan Philaret (Drozdov) The article aims to present the sources of Russian conservatism, based on the Metropolitan Filaret (Drozdov) works.
Dymitr Romanowski
doaj +1 more source
How Unique Was The Chicago Tradition? - Introduction [PDF]
, 2003 The first part of this chapter describes and elaborates upon the contributions made to this expanding literature by Tom Cate, J. Ronnie Davis, David Laidler, Joseph Aschheim and George Tavlas regarding the claim that inter-war Chicago exhibited unique ...
Leeson, Robert
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Beyond survey design: Lessons from conducting the National Adolescent Mental Health Surveys
Child and Adolescent Psychiatry and Mental HealthBackground The National Adolescent Mental Health Surveys (NAMHS) were the result of a six-year collaboration between five organisations from five countries.
Holly E. Erskine +6 more
doaj +1 more source
Impartiality, Close Friendships and the Confucian Tradition [PDF]
, 2017 This article explores the relationship between friendship and morality. Two ideas have been influential in the history of moral philosophy: the impartial standpoint and close friendship.
Lambert, Andrew
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source