Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Analysis and control of a unified power flow controller system
, 1998 The Unified Power Flow Controller (UPFC)modeled in the synchronous reference frame is investigated in this thesis for the control of power flow in a transmission system.
Zhu, Xin.
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Data-Rich But Integration-Poor Human Trials: Conceptual Framework for Closing the AI Transformation Gap in Dietary Intervention and Cosmetic Human Trials. [PDF]
J Med Internet ResLee S, Lee S, Lee S, Yoo H, Cho JM.
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Dispensing system having weight dependent control means
, 1985 The present invention relates to a dispensing system for supplying and administering a metered dose of a material to an animal subject wherein the amount of the material supplied is a function of the weight of the subject.
Smith, Clifford J.
core
A Novel Informatics-Driven Model for Proactive Radiation Safety Management: Lessons from a Tumor Specialist Hospital in China. [PDF]
Risk Manag Healthc PolicyTian Q +5 more
europepmc +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Analysis of workers' dose records from the Greek dose registry information system
, 1995 The object of this work is the study of the individual film badge annual dose information of classified workers in Greece, monitored and assessed by the central dosimetry service of the Greek Atomic Energy Commission.
Kamenopoulou, V. +3 more
core +1 more source