Results 131 to 140 of about 187,916,210 (222)

Adjunctive non-pharmacological interventions for motor symptoms in Parkinson's disease: a scoping review of randomized controlled trials. [PDF]

Front Neurol
Wang Z, Ruan J, Zhang M, Li C.
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Computational modeling and preclinical evaluation support targeting somatic instability for Huntington's disease treatment. [PDF]

Nat Commun
Simpson BP, Ranum PT, Leib DE, Tecedor L, Giovenco RC, Huerta-Ocampo I, Hundley AA, Smith N, Fluta CM, Cali CP, Benoit J, Soper JC, Connelly J, Yohrling GJ, Ghoroghchian PP, Cha JJ, Davidson BL.   +16 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Coordinated Regulation of Orchard Variable-Rate Spraying: From Canopy Perception to Actuation-A Review. [PDF]

Sensors (Basel)
Dai S, Tu D, Fan X, Wang M, Zhang Z, Zhu W, Jiang L, Zhou J, Jia W.   +8 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

How to get your Hanford radiation dose estimate: individual thyroid dose estimate for Iodine 131 released to the air from Hanford, December 26, 1944 - December 31, 1957

This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes."A public service program of Idaho Department of health and ...

core  

Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association. [PDF]

Front Aging Neurosci
Gonçalves AR, Mendes A, Damásio J, Vila-Chã N, Boleixa D, Santos C, Leal B, Cavaco S.   +7 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Modeling physiological insulin sensitivity and pre-diabetic insulin resistance in multiple hPSC-derived cell types. [PDF]

Signal Transduct Target Ther
Friesen M, Jaenisch R.
europepmc   +1 more source